In vivo characterization of the mechanical properties of human skin derived from MRI and indentation techniques

The human skin is an exceedingly complex and multi-layered material. This paper aims to introduce the application of the finite element analysis (FEA) to the in vivo characterization of the non-linear mechanical behaviour of three human skin layers. Indentation tests combined with magnetic resonance...

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Bibliographic Details
Published in:Computer methods in biomechanics and biomedical engineering 2007-12, Vol.10 (6), p.401-407
Main Authors: Tran, H. V., Charleux, F., Rachik, M., Ehrlacher, A., Ho Ba Tho, M. C.
Format: Article
Language:English
Subjects:
Anisotropy
Biomechanical Phenomena - methods
Computer Simulation
Elasticity
FEM
Hardness
Hardness Tests - methods
Humans
Hyper-elastic
Identification method
Image Interpretation, Computer-Assisted - methods
Indentation
Life Sciences
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mechanical properties human skin
Models, Biological
Skin - anatomy & histology
Skin Physiological Phenomena
Viscosity
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Summary:The human skin is an exceedingly complex and multi-layered material. This paper aims to introduce the application of the finite element analysis (FEA) to the in vivo characterization of the non-linear mechanical behaviour of three human skin layers. Indentation tests combined with magnetic resonance imaging (MRI) technique have been performed on the left dorsal forearm of a young man in order to reveal the mechanical behaviour of all skin layers. Using MRI images processing and a pre and post processor allows to make numerically individualized 2D model which consists of three skin layers and the muscles. FEA has been applied to simulate indentation tests. Neo-Hookean slightly compressible material model of two material constants (C 10 , K) has been used to model the mechanical behaviour of the three skin layers and the muscles. The identification of material model parameters was done by applying Levenberg-Marquardt algorithm (LMA). Our methodology of identification provides a range of values for each constant. Range of values of different material properties of epidermis, dermis, hypodermis are respectively, C10 E  = 0.12 ± 0.06 MPa, C10 D  = 1.11 ± 0.09 MPa, C10 H  = 0.42 ± 0.05 KPa, K E  = 5.45 ± 1.7 MPa, K D  = 29.6 ± 1,28 MPa, K H  = 36.0 ± O.9 KPa.
ISSN:1025-5842
1476-8259
DOI:10.1080/10255840701550287