The identification and evaluation of ATP binding cassette systems in the intracellular bacterium Francisella tularensis

Francisella tularensis is a facultative intracellular bacterium responsible for the disease tularemia. Analysis of the fully sequenced genome of the virulent F. tularensis strain SCHU S4 has led to the identification of twenty ATP binding cassette (ABC) systems, of which five appear to be non-functi...

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Bibliographic Details
Published in:Research in microbiology 2006-07, Vol.157 (6), p.593-604
Main Authors: Atkins, Helen S., Dassa, Elie, Walker, Nicola J., Griffin, Kate F., Harland, David N., Taylor, Rosa R., Duffield, Melanie L., Titball, Richard W.
Format: Article
Language:English
Subjects:
ABC
Animals
ATP-Binding Cassette Transporters
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - immunology
ATP-Binding Cassette Transporters - physiology
Bacterial
Bacterial Typing Techniques
Bacterial Vaccines
Bacterial Vaccines - immunology
Bacteriology
Biochemistry, Molecular Biology
Biological and medical sciences
Biological Transport
Female
Francisella tularensis
Francisella tularensis - genetics
Francisella tularensis - immunology
Francisella tularensis - metabolism
Fundamental and applied biological sciences. Psychology
Genome
Life Sciences
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Phylogeny
Sequence Analysis, DNA
Vaccines, DNA
Vaccines, DNA - immunology
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Summary:Francisella tularensis is a facultative intracellular bacterium responsible for the disease tularemia. Analysis of the fully sequenced genome of the virulent F. tularensis strain SCHU S4 has led to the identification of twenty ATP binding cassette (ABC) systems, of which five appear to be non-functional. The fifteen complete systems comprise three importers, five exporters, four systems involved in non-transport processes, and three systems of unknown or ill-defined function. The number and classification of the ABC systems in F. tularensis is similar to that observed in other intracellular bacteria, indicating that some of these systems may be important for the intracellular lifestyle of these organisms. Among the ABC systems identified in the genome are systems that may be involved in the virulence of F. tularensis SCHU S4. Six ABC system proteins were evaluated as candidate vaccine antigens against tularemia, although none provided significant protection against F. tularensis. However, a greater understanding of these systems may lead to the development of countermeasures against F. tularensis.
ISSN:0923-2508
1769-7123
0923-2508
DOI:10.1016/j.resmic.2005.12.004