High-resolution crystallography and drug design

Ultra‐high‐resolution X‐ray crystallography of macromolecules (i.e. resolution better than 0.8 Å) is a rising field that promises to provide new insight into the structure–function relationships of biomacromolecules. The picture emerging from macromolecular structures at this resolution is far more...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular recognition 2005-05, Vol.18 (3), p.196-202
Main Authors: Cachau, R. E., Podjarny, A. D.
Format: Article
Language:English
Subjects:
Animals
Biochemistry, Molecular Biology
Crystallography, X-Ray
Drug Design
Humans
Life Sciences
macromolecular crystallography
Macromolecular Substances
Macromolecular Substances - chemistry
Models, Molecular
Molecular biology
Protein Conformation
ultra-high resolution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ultra‐high‐resolution X‐ray crystallography of macromolecules (i.e. resolution better than 0.8 Å) is a rising field that promises to provide new insight into the structure–function relationships of biomacromolecules. The picture emerging from macromolecular structures at this resolution is far more complex than previously understood, requiring for its study improved tools for structure refinement, analysis and annotation. Some of these problems were highlighted during the recent High Resolution Drug Design Meeting (Bischenberg‐Strasbourg, France, 13–16 May 2004). We will review here some of the results and discussions that took place during that meeting and elaborate on the trends and challenges ahead in this emerging new field of research. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0952-3499
1099-1352
DOI:10.1002/jmr.738