A Variation in the Ghrelin Gene Increases Weight and Decreases Insulin Secretion in Tall, Obese Children

Ghrelin is a recently recognized gut-brain peptide originally derived from the gastric mucosa. It stimulates growth hormone release, increases appetite and facilitates fat storage, and may interact with glucose metabolism. We studied the ghrelin gene in a group of 70 tall and obese children (mean ag...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2002-08, Vol.87 (8), p.4005-4008
Main Authors: Korbonits, Márta, Gueorguiev, Maria, O’Grady, Eithne, Lecoeur, Cecile, Swan, Daniel C, Mein, Charles A, Weill, Jacques, Grossman, Ashley B, Froguel, Philippe
Format: Article
Language:English
Subjects:
Body Height
Body Weight
Child
Child, Preschool
Genetics
Glucose Tolerance Test
Human genetics
Humans
Insulin
Life Sciences
Motilin
Obesity
Peptide Hormones
Peptides
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
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Summary:Ghrelin is a recently recognized gut-brain peptide originally derived from the gastric mucosa. It stimulates growth hormone release, increases appetite and facilitates fat storage, and may interact with glucose metabolism. We studied the ghrelin gene in a group of 70 tall and obese children (mean age 9.4 year, Z body mass index [BMI] and Z height >3 and/or BMI percentile >99%). We found 10 single nucleotide polymorphisms. One common polymorphism of the ghrelin gene, which corresponds to an amino acid change in the tail of the prepro-ghrelin molecule, was significantly associated with children with a higher BMI (P = 0.001), and with lower insulin secretion during the first part of an oral glucose tolerance test (P = 0.05) although no difference in glucose levels was noted. This might suggest increased insulin sensitivity, although this is not supported by the lack of difference in fasting and 2 hour insulin levels; alternatively, this may be indicative of impaired first phase insulin secretion. These data suggest that variations in the ghrelin gene contribute to obesity in children and may modulate glucose-induced insulin secretion.
ISSN:0021-972X
1945-7197
DOI:10.1210/jcem.87.8.8881