Fluorescent nanoparticles as selective Cu(II) sensors

Latex nanoparticles functionalized with cyclam (1,4,8,11-tetraazacyclotetradecane), a copper chelator, have been doped with a fluorescent dye (BODIPY derivative: 4,4-difluoro-8-(2',4',6'-trimethyl)phenyl-2,6-diethyl-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene). The bulky, hydrop...

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Bibliographic Details
Published in:Photochemical & photobiological sciences 2006-03, Vol.5 (3), p.300-310
Main Authors: Méallet-Renault, Rachel, Hérault, Alexandre, Vachon, Jean-Jacques, Pansu, Robert B, Amigoni-Gerbier, Sonia, Larpent, Chantal
Format: Article
Language:English
Subjects:
Boron Compounds - chemical synthesis
Boron Compounds - chemistry
Chelating Agents - chemistry
Copper - chemistry
Energy Transfer
Fluorescence Polarization - methods
Fluorescent Dyes - chemistry
Heterocyclic Compounds - chemistry
Heterocyclic Compounds, 3-Ring - chemical synthesis
Heterocyclic Compounds, 3-Ring - chemistry
Nanostructures - chemistry
Sensitivity and Specificity
Spectrometry, Fluorescence - methods
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Summary:Latex nanoparticles functionalized with cyclam (1,4,8,11-tetraazacyclotetradecane), a copper chelator, have been doped with a fluorescent dye (BODIPY derivative: 4,4-difluoro-8-(2',4',6'-trimethyl)phenyl-2,6-diethyl-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene). The bulky, hydrophobic fluorophore dissolves within the nanoparticles' polymer core up to a concentration of about 88.4 micromol g(-1). At this concentration the fluorescence yield is about 0.80. Adding Cu2+ ions to the solution decreases the fluorescence because of the energy transfer between the dye and the violet copper cyclam complexes. The response is fast: 90% of the quenching occurs within 1 s. The Cu2+ detection threshold is of 1 nanomolar. No interferences were observed with zinc and nickel ions.
ISSN:1474-905X
1474-9092
DOI:10.1039/b513215k