A Comprehensive Analysis of Volumetric PET/CT Parameters, Clinical and Histopathologic Features: Evaluation of the Predictive Role

Objectives: To evaluate the relationships between volumetric [.sup. (68)Ga-prostate-specific] membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) parameters, Gleason score (GS), prostate-specific antigen (PSA) levels, histopathological data, and metastatic status in new...

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Bibliographic Details
Published in:Molecular imaging and radionuclide therapy 2024-06, Vol.33 (2), p.68
Main Authors: Mutevelizade, Gozde, Parlak, Yasemin, Arikbasi, Ceren Sezgin, Gumuser, Gul, Sayit, Elvan
Format: Article
Language:English
Subjects:
Care and treatment
CT imaging
Diagnosis
Methods
PET imaging
Prostate cancer
Volumetric analysis
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Summary:Objectives: To evaluate the relationships between volumetric [.sup. (68)Ga-prostate-specific] membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) parameters, Gleason score (GS), prostate-specific antigen (PSA) levels, histopathological data, and metastatic status in newly diagnosed prostate cancer (PCa) patients and to assess the predictive factors for progression despite treatment. Methods: A total of 78 newly diagnosed patients with PCa who had [.sup.68Ga-PSMA] PET/CT scans were included. Clinical parameters, histopathological data, and metastatic status were documented, and volumetric parameters of primary prostate lesions were measured. All obtained data were compared statistically. Results: Primary prostate tumor maximum standardized uptake value ([SUV.sub.max] ) and GS were significantly related to serum PSA levels (p
ISSN:2146-1414
DOI:10.4274/mirt.galenos.2024.56933