Effect of Heat-Treated ILactiplantibacillus plantarum/I nF1 on the Immune System Including Natural Killer Cell Activity: A Randomized, Placebo-Controlled, Double-Blind Study

Heat-treated Lactiplantibacillus plantarum nF1 (HT-nF1) increases immune cell activation and the production of various immunomodulators (e.g., interleukin (IL)-12) as well as immunoglobulin (Ig) G, which plays an important role in humoral immunity, and IgA, which activates mucosal immunity. To deter...

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Bibliographic Details
Published in:Nutrients 2024-05, Vol.16 (9)
Main Authors: Hong, Geun-Hye, Lee, So-Young, Kim, In Ah, Suk, Jangmi, Baeg, Chaemin, Kim, Ji Yeon, Lee, Sehee, Kim, Kyeong Jin, Kim, Ki Tae, Kim, Min Gee, Park, Kun-Young
Format: Article
Language:English
Subjects:
Ethylenediaminetetraacetic acid
Immunoglobulin A
Killer cells
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Summary:Heat-treated Lactiplantibacillus plantarum nF1 (HT-nF1) increases immune cell activation and the production of various immunomodulators (e.g., interleukin (IL)-12) as well as immunoglobulin (Ig) G, which plays an important role in humoral immunity, and IgA, which activates mucosal immunity. To determine the effect of HT-nF1 intake on improving immune function, a randomized, double-blind, placebo-controlled study was conducted on 100 subjects with normal white blood cell counts. The HT-nF1 group was administered capsules containing 5 × 10[sup.11] cells of HT-nF1 once a day for 8 weeks. After 8 weeks of HT-nF1 intake, significant changes in IL-12 were observed in the HT-nF1 group (p = 0.045). In particular, the change in natural killer (NK) cell activity significantly increased in subjects with low secretory (s) IgA (≤49.61 μg/mL) and low NK activity (E:T = 10:1) (≤3.59%). These results suggest that HT-nF1 has no safety issues and improves the innate immune function by regulating T helper (Th)1-related immune factors. Therefore, we confirmed that HT-nF1 not only has a positive effect on regulating the body’s immunity, but it is also a safe material for the human body, which confirms its potential as a functional health food ingredient.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16091339