Biochanin A inhibits endothelial dysfunction induced by IL-6-stimulated endothelial microparticles in Perthes disease via the NF[kappa]B pathway

Endothelial dysfunction caused by the stimulation of endothelial microparticles (EMPs) by the inflammatory factor IL-6 is one of the pathogenic pathways associated with Perthes disease. The natural active product biochanin A (BCA) has an anti-inflammatory effect; however, whether it can alleviate en...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2024-04, Vol.27 (4)
Main Authors: Liu, Jianhong, Lin, Chengsen, Li, Boxiang, Huang, Qian, Chen, Xianxiang, Tang, Shengping, Luo, Xiaolin, Lu, Rongbin, Liu, Yun, Liao, Shijie, Ding, Xiaofei
Format: Article
Language:English
Subjects:
Care and treatment
Complications and side effects
Development and progression
Health aspects
Interleukin-6
Isoflavones
Legg-Calve-Perthes disease
Physiological aspects
Vascular endothelium
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Summary:Endothelial dysfunction caused by the stimulation of endothelial microparticles (EMPs) by the inflammatory factor IL-6 is one of the pathogenic pathways associated with Perthes disease. The natural active product biochanin A (BCA) has an anti-inflammatory effect; however, whether it can alleviate endothelial dysfunction in Perthes disease is not known. The present in vitro experiments on human umbilical vein endothelial cells showed that 0-100 pg/ml IL-6-EMPs could induce endothelial dysfunction in a concentration-dependent manner, and the results of the Cell Counting Kit 8 assay revealed that, at concentrations of
ISSN:1792-0981
DOI:10.3892/etm.2024.12425