Structures and Biological Activities of Secondary Metabolites from IXylaria/I spp

The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylari...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2024-02, Vol.10 (3)
Main Authors: Chen, Weikang, Yu, Miao, Chen, Shiji, Gong, Tianmi, Xie, Linlin, Liu, Jinqin, Bian, Chang, Huang, Guolei, Zheng, Caijuan
Format: Article
Language:English
Subjects:
Antifungal agents
Enzymes
Fungi
Lactones
Plant metabolites
Online Access:Get full text
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Summary:The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from Xylaria and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof10030190