Nitrofuran Derivatives Cross-Resistance Evidence—Uropathogenic IEscherichia coli/I Nitrofurantoin and Furazidin In Vitro Susceptibility Testing

The treatment of urinary tract infections is usually empirical. For example, nitrofuran derivatives, mainly nitrofurantoin (but also furazidin), are used in Eastern Europe. A significant problem is the assessment of the usefulness of furazidin, as there are no standards for susceptibility testing. A...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-08, Vol.12 (16)
Main Authors: Bielec, Filip, Brauncajs, Małgorzata, Pastuszak-Lewandoska, Dorota
Format: Article
Language:English
Subjects:
Drug resistance in microorganisms
Drug therapy
Escherichia coli
Methods
Microbial sensitivity tests
Nitrofurantoin
Risk factors
Testing
Urinary tract infections
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Summary:The treatment of urinary tract infections is usually empirical. For example, nitrofuran derivatives, mainly nitrofurantoin (but also furazidin), are used in Eastern Europe. A significant problem is the assessment of the usefulness of furazidin, as there are no standards for susceptibility testing. Additionally, a high percentage of strains resistant to nitrofurantoin should prompt caution when choosing furazidin in therapy. This study aimed to answer the question of whether it is possible to use nitrofurantoin susceptibility for furazidin drug susceptibility analyses and if there is any cross-resistance in the nitrofuran derivatives group. One hundred E. coli clinical isolates, obtained from the Central Teaching Hospital of the Medical University of Lodz, were cultured from positive urine samples. For susceptibility testing, microdilution and disk diffusion methods, following EUCAST guidelines, were used. The results showed that the MICs of furazidin were equal to or lower than those of nitrofurantoin in 89% of the tested strains. The MIC[sub.50/90] values for furazidin were two times lower than those for nitrofurantoin. Positive correlations were found between MICs and growth inhibition zones for both antibiotics. Based on the obtained data and previous studies, it was assumed that the transfer of susceptibility testing results from nitrofurantoin to furazidin is acceptable due to cross-resistance in nitrofuran derivatives.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12165166