Vector Competence of ICulex quinquefasciatus/I from Brazil for IWest Nile Virus/I

West Nile virus is characterized as a neurotropic pathogen, which can cause West Nile fever and is transmitted by mosquitoes of the genus Culex. In 2018, the Instituto Evandro Chagas performed the first isolation of a WNV strain in Brazil from a horse brain sample. The present study aimed to evaluat...

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Bibliographic Details
Published in:Tropical medicine and infectious disease 2023-04, Vol.8 (4)
Main Authors: Reis, Lúcia Aline Moura, Silva, Eliana Vieira Pinto da, Dias, Daniel Damous, Freitas, Maria Nazaré Oliveira, Caldeira, Rossela Damasceno, Araújo, Pedro Arthur da Silva, Silva, Fábio Silva da, Rosa Junior, José Wilson, Brandão, Roberto Carlos Feitosa, Nascimento, Bruna Laís Sena do, Ma, Neto, Joaquim Pinto Nunes
Format: Article
Language:English
Subjects:
Brazil
Diseases
Genetic vectors
Health aspects
Mosquitoes
West Nile fever
Online Access:Get full text
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Summary:West Nile virus is characterized as a neurotropic pathogen, which can cause West Nile fever and is transmitted by mosquitoes of the genus Culex. In 2018, the Instituto Evandro Chagas performed the first isolation of a WNV strain in Brazil from a horse brain sample. The present study aimed to evaluate the susceptibility of orally infected Cx. quinquefasciatus from the Amazon region of Brazil to become infected and transmit the WNV strain isolated in 2018. Oral infection was performed with blood meal artificially infected with WNV, followed by analysis of infection, dissemination, and transmission rates, as well as viral titers of body, head, and saliva samples. At the 21st dpi, the infection rate was 100%, the dissemination rate was 80%, and the transmission rate was 77%. These results indicate that Cx. quinquefasciatus is susceptible to oral infection by the Brazilian strain of WNV and may act as a possible vector of the virus since it was detected in saliva from the 21st dpi.
ISSN:2414-6366
2414-6366
DOI:10.3390/tropicalmed8040217