New Triterpenoids and Anti-Inflammatory Constituents from IGlinus oppositifolius/I

Three new triterpenoids-spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)-were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (4-20). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-03, Vol.28 (7)
Main Authors: Chen, Jih-Jung, Yang, Chang-Syun, Chen, Yu-Hui, Chao, Che-Yi, Chen, Yu-Chang, Kuo, Yeuh-Hsiung
Format: Article
Language:English
Subjects:
Anti-inflammatory drugs
Bioflavonoids
Flavones
Flavonoids
Medicine, Botanic
Medicine, Herbal
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Summary:Three new triterpenoids-spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)-were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (4-20). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and 20 were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC[sub.50] values of 17.03, 18.21, 16.30, and 12.64 μM, respectively. Compounds 3, 5, and 20 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC[sub.50] values of 18.35 ± 1.34, 17.56 ± 1.41, and 14.27 ± 1.29 μM, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28072903