Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus/Sistemik lupus eritematozuslu hastalarda lupus nefriti ve lupus disi nefritlerin karsilastirilmasi

Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus/Sistemik lupus eritematozuslu hastalarda lupus nefriti ve lupus disi nefritlerin karsilastirilmasi

Objective: Kidney biopsy may unusually show non-lupus nephritis (LN) causes in patients with systemic lupus erythematosus (SLE). This study aimed to reveal the causes of non-LN and to compare the clinical and laboratory features of LN and non-lupus renal disease in patients with SLE. Methods: Patien...

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Published in:Journal of Turkish Society for Rheumatology 2023-04, Vol.15 (1), p.18
Main Authors: Duran, Emine, Yildirim, Tolga, Taghiyeva, Arzu, Bilgin, Emre, Arici, Mustafa, Saglam, Arzu, Ozen, Seza, Uner, Meral, Erdem, Yunus, Kalyoncu, Umut, Ertenli, Ihsan
Format: Article
Language:eng
Subjects:
Albumin
Autoantibodies
Care and treatment
Comparative analysis
Lupus
Medical research
Medicine, Experimental
Nephritis
Systemic lupus erythematosus
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Summary:Objective: Kidney biopsy may unusually show non-lupus nephritis (LN) causes in patients with systemic lupus erythematosus (SLE). This study aimed to reveal the causes of non-LN and to compare the clinical and laboratory features of LN and non-lupus renal disease in patients with SLE. Methods: Patients with SLE followed between 2014 and 2020 at Hacettepe University Hospitals and who had kidney biopsy were the subject of the study. One hundred thirty four patients' kidney biopsies were evaluated retrospectively and grouped as LN and non-LN. Clinical characteristics, laboratory values at the time of kidney biopsy, and renal outcome were recorded. Results: Of 134 (107 females, 27 males) patients, 116 (86.6%) were in the LN group, and 18 (13.4%) were in the non-LN group. The most common diagnosis was focal segmental glomerulosclerosis (n=6) in the non-LN group. The median (interquartile range) biopsy age of LN patients was young [21 (17.7) vs. 36.5 (17), p
ISSN:2651-2653