Chronic Mercury Exposure and IGSTP1/I Polymorphism in Munduruku Indigenous from Brazilian Amazon

Genetic polymorphisms may be involved with mercury levels and signs and symptoms of intoxication from this exposure. Therefore, the aims were to describe the frequency of the GSTP1 polymorphism and to evaluate its effects on mercury levels and neurological signs in three Munduruku indigenous village...

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Bibliographic Details
Published in:Toxics (Basel) 2023-01, Vol.11 (2)
Main Authors: Silva, Mayara Calixto da, Oliveira, Rogério Adas Ayres de, Vasconcellos, Ana Claudia Santiago de, Rebouças, Bruno Hojo, Pinto, Bruna Duarte, Lima, Marcelo de Oliveira, Jesus, Iracina Maura de, Machado, Daniel Escorsim, Hacon, Sandra Souza, Basta, Paulo Cesar, Perini, Jamila Alessandra
Format: Article
Language:English
Subjects:
Analysis
Genetic aspects
Genetic polymorphisms
Glutathione transferase
Indigenous peoples
Mercury
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Summary:Genetic polymorphisms may be involved with mercury levels and signs and symptoms of intoxication from this exposure. Therefore, the aims were to describe the frequency of the GSTP1 polymorphism and to evaluate its effects on mercury levels and neurological signs in three Munduruku indigenous villages in the Brazilian Amazon. One-hundred-and-seven indigenous (over 12 years old) were included and genotyped (rs1695) using a TaqMan validated assay. Then, associations were evaluated by binary logistic regression, using odds ratios (OR) and 95% confidence intervals (CI). Mean age was 27.4 ± 13.9 years old, 52.3% were male, mean hair mercury concentration was 8.5 ± 4.3, exceeding the reference limit (≥6.0 µg/g), and were different among the three villages: 13.5 ± 4.6 µg/g in Sawré Aboy, 7.4 ± 2.3 µg/g in Poxo Muybu and 6.9 ± 3.5 µg/g in Sawré Muybu. The minor allele frequency of GSTP1 G was significantly different among the villages: 57% Sawré Muybu, 21% Poxo Muybu and 15% Sawré Aboy. Finally, after adjustment, GSTP1 GG and GA genotypes were associated with lower levels of Hg (OR = 0.13; CI95% = 0.03–0.49) and abnormal somatosensory signs (OR = 3.7; 95%IC = 1.5–9.3), respectively. In conclusion, monitoring this population is imperative to identify individuals at higher risk of developing signs of chronic mercury exposure based on the genetic profile.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics11020138