Study of Serum Vitamin B12, Vitamin D3 Levels, Serum Telomerase Changes in Patients with Depression

Depression affects approximately 121 million people worldwide and is the leading cause of disability. WHO data predicts that depression shall be the second cause of global disease burden by the year 2020. Depression is associated with selected nutritional deficiency such as Vitamin B12, Vitamin D. T...

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Published in:Indian journal of clinical biochemistry 2022-05, Vol.34 (S1), p.S198
Main Authors: Rattan, Roma, Mandal, M.K, Das, Upendra Kumar, Sarangi, Pratikhya, Pradhan, Devi Prasad, Lamare, Andrew Abel, Panda, Mrutyunjaya, Jena, Sudeep
Format: Article
Language:English
Subjects:
Alfacalcidol
Analysis
Calcifediol
Care and treatment
Depression, Mental
Enzymes
Telomerase
Telomeres
Vitamin D
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Summary:Depression affects approximately 121 million people worldwide and is the leading cause of disability. WHO data predicts that depression shall be the second cause of global disease burden by the year 2020. Depression is associated with selected nutritional deficiency such as Vitamin B12, Vitamin D. The pathophysiology of disease development and response to treatment is unclear. Research is being aimed at revealing its pathophysiology at a cellular and molecular level. An important locus of cellular damage and ageing is "Leucocyte telomere length". Telomere shortening is implicated in cellular ageing. Telomerase, a ribonucleoprotein enzyme is responsible for repairing, protecting and maintaining telomere length. Hence, this study aims (i) at evaluating serum Vitamin B12, Vitamin D3 and serum telomerase level in patients with depression; (ii) association of serum telomerase level with severity of depression. The study included 48 patients with depression and equal number of matched healthy volunteers. The severity of depression was assessed by HAMILTON Depression Score. Serum Vitamin B12 and Vitamin D3 were measured by Chemiluminescence kits adapted to Cobas e411, Roche diagnostics. Serum Telomerase was estimated by ELISA kits adapted to automated ELISA system, Biorad. The data was analyzed by the statistical software SPSS version 24.We observed significant lower Vitamin B12, Vitamin D3 and serum Telomerase activity among the patients with depression, as compared to healthy individuals. A significant inverse correlation was observed between serum Telomerase activity and severity of depression. The study implicates the role of serum Telomerase as a novel prognostic marker for depression. Further, and increased study population can elucidate the optimum role of Telomerase in the pathophysiology of depression. We also suggest that status of Vitamin B12 and D3 should be evaluated and nutritional supplement should be given.
ISSN:0970-1915
0974-0422