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Cytotoxic, Thrombolytic and Antibacterial Evaluation of Synthesized Substituted and Un-Substituted Selenium-N-Heterocyclic Carbene Adducts
Alkyl-substituted azolium salts (1-8) and their Se-N-heterocyclic carbene (Se-N-Het-C) adducts (9-12) were obtained in very reasonable yields. All synthesized azolium salts and their Se-N-Het-C adducts were characterized by different spectroscopic techniques such as FT-IR, 1HNMR, 13CNMR, and element...
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Published in: | Journal of the Chemical Society of Pakistan 2023-02, Vol.45 (1), p.44-44 |
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container_title | Journal of the Chemical Society of Pakistan |
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creator | Amna Kamal, Amna Kamal Muhammad Adnan Iqbal, Muhammad Adnan Iqbal Haq Nawaz Bhatti and Abdul Ghaffar, Haq Nawaz Bhatti and Abdul Ghaffar |
description | Alkyl-substituted azolium salts (1-8) and their Se-N-heterocyclic carbene (Se-N-Het-C) adducts (9-12) were obtained in very reasonable yields.
All synthesized azolium salts and their Se-N-Het-C adducts were characterized by different spectroscopic techniques such as FT-IR, 1HNMR, 13CNMR, and elemental analysis. It was found that all synthesized Se-N-Het-C adducts were stable at room temperature in both air and moisture. In-vitro these compounds (5-12) were assessed for their antimicrobial potential against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis), and Bacillus cereus (B. cereus) in vitro. Results of MIC and inhibition zone values revealed that the majority of the Selenium N-Heterocyclic carbene adducts were active against Bacillus subtilis (B. subtilis) than Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) whereas opposite in the azolium salts (5-8). Compounds 5-8 have an inhibition zone of 16and#177;0.1-26and#177;0.3mm against all tested bacterial strains while selenium-NHC adducts 9-12 have a zone of inhibition (16and#177;0.2 to 25 and#177; 0.4mm). Adduct 12 showed good activity against all tested strains with ZI values 25 and#177; 0.1, 22and#177; 0.5, 17 and#177; 0.3 mm and MIC values 17 and#177; 0.2, 16 and#177; 0.4 and 18 and#177; 0.3 and#181;g/mL against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) respectively. Adduct 10 showed the highest thrombolysis i-e 86.9% and adduct 12 showed good hemolysis i-e 0.51%. Overall results of thrombolysis and cytotoxicity studies revealed that the compounds are safe for preclinical studies of mouse blood in vitro. |
doi_str_mv | 10.52568/001198/JCSP/45.01.2023 |
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All synthesized azolium salts and their Se-N-Het-C adducts were characterized by different spectroscopic techniques such as FT-IR, 1HNMR, 13CNMR, and elemental analysis. It was found that all synthesized Se-N-Het-C adducts were stable at room temperature in both air and moisture. In-vitro these compounds (5-12) were assessed for their antimicrobial potential against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis), and Bacillus cereus (B. cereus) in vitro. Results of MIC and inhibition zone values revealed that the majority of the Selenium N-Heterocyclic carbene adducts were active against Bacillus subtilis (B. subtilis) than Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) whereas opposite in the azolium salts (5-8). Compounds 5-8 have an inhibition zone of 16and#177;0.1-26and#177;0.3mm against all tested bacterial strains while selenium-NHC adducts 9-12 have a zone of inhibition (16and#177;0.2 to 25 and#177; 0.4mm). Adduct 12 showed good activity against all tested strains with ZI values 25 and#177; 0.1, 22and#177; 0.5, 17 and#177; 0.3 mm and MIC values 17 and#177; 0.2, 16 and#177; 0.4 and 18 and#177; 0.3 and#181;g/mL against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) respectively. Adduct 10 showed the highest thrombolysis i-e 86.9% and adduct 12 showed good hemolysis i-e 0.51%. Overall results of thrombolysis and cytotoxicity studies revealed that the compounds are safe for preclinical studies of mouse blood in vitro.</description><identifier>ISSN: 0253-5106</identifier><identifier>DOI: 10.52568/001198/JCSP/45.01.2023</identifier><language>eng</language><publisher>Knowledge Bylanes</publisher><subject>Analysis ; Carbenes ; Chemical synthesis ; Heterocyclic compounds ; Identification and classification ; Methods ; Properties ; Selenium</subject><ispartof>Journal of the Chemical Society of Pakistan, 2023-02, Vol.45 (1), p.44-44</ispartof><rights>COPYRIGHT 2023 Knowledge Bylanes</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-4ceeaa30d19c78deb52338c1ae7bc0bb02827ebb5151c9524a7db790de87f4e23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Amna Kamal, Amna Kamal</creatorcontrib><creatorcontrib>Muhammad Adnan Iqbal, Muhammad Adnan Iqbal</creatorcontrib><creatorcontrib>Haq Nawaz Bhatti and Abdul Ghaffar, Haq Nawaz Bhatti and Abdul Ghaffar</creatorcontrib><title>Cytotoxic, Thrombolytic and Antibacterial Evaluation of Synthesized Substituted and Un-Substituted Selenium-N-Heterocyclic Carbene Adducts</title><title>Journal of the Chemical Society of Pakistan</title><description>Alkyl-substituted azolium salts (1-8) and their Se-N-heterocyclic carbene (Se-N-Het-C) adducts (9-12) were obtained in very reasonable yields.
All synthesized azolium salts and their Se-N-Het-C adducts were characterized by different spectroscopic techniques such as FT-IR, 1HNMR, 13CNMR, and elemental analysis. It was found that all synthesized Se-N-Het-C adducts were stable at room temperature in both air and moisture. In-vitro these compounds (5-12) were assessed for their antimicrobial potential against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis), and Bacillus cereus (B. cereus) in vitro. Results of MIC and inhibition zone values revealed that the majority of the Selenium N-Heterocyclic carbene adducts were active against Bacillus subtilis (B. subtilis) than Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) whereas opposite in the azolium salts (5-8). Compounds 5-8 have an inhibition zone of 16and#177;0.1-26and#177;0.3mm against all tested bacterial strains while selenium-NHC adducts 9-12 have a zone of inhibition (16and#177;0.2 to 25 and#177; 0.4mm). Adduct 12 showed good activity against all tested strains with ZI values 25 and#177; 0.1, 22and#177; 0.5, 17 and#177; 0.3 mm and MIC values 17 and#177; 0.2, 16 and#177; 0.4 and 18 and#177; 0.3 and#181;g/mL against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) respectively. Adduct 10 showed the highest thrombolysis i-e 86.9% and adduct 12 showed good hemolysis i-e 0.51%. Overall results of thrombolysis and cytotoxicity studies revealed that the compounds are safe for preclinical studies of mouse blood in vitro.</description><subject>Analysis</subject><subject>Carbenes</subject><subject>Chemical synthesis</subject><subject>Heterocyclic compounds</subject><subject>Identification and classification</subject><subject>Methods</subject><subject>Properties</subject><subject>Selenium</subject><issn>0253-5106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNptUU1Lw0AQzUHBUv0NBryadj-y3eRYQrWKqFB7XvZjYleSXcluxPgT_NWm1oOCM4cZHu-9gXlJco7RjBG2KOYIYVwW89tq8zjP2QzhGUGEHiUTRBjNGEaLk-QshBc01oJwuqCT5LMaoo_-3erL9GnX-Vb5ZohWp9KZdOmiVVJH6Kxs0tWbbHoZrXepr9PN4OIOgv0Ak256FaKNfRz3vW7rst_QBhpwtm-z-2wNo5nXg27GE5XsFDhIl8b0OobT5LiWTYCznzlNtlerp2qd3T1c31TLu0xTkscs1wBSUmRwqXlhQDFCaaGxBK40UgqRgnBQimGGdclILrlRvEQGCl7nQOg0uTj4PssGhHW1j53UrQ1aLDkt8vGJ5Z41-4c1toHWau-gtiP-R8APAt35EDqoxWtnW9kNAiPxHZA4BCT2AYmcCYTFPiD6BZxdiMs</recordid><startdate>20230228</startdate><enddate>20230228</enddate><creator>Amna Kamal, Amna Kamal</creator><creator>Muhammad Adnan Iqbal, Muhammad Adnan Iqbal</creator><creator>Haq Nawaz Bhatti and Abdul Ghaffar, Haq Nawaz Bhatti and Abdul Ghaffar</creator><general>Knowledge Bylanes</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230228</creationdate><title>Cytotoxic, Thrombolytic and Antibacterial Evaluation of Synthesized Substituted and Un-Substituted Selenium-N-Heterocyclic Carbene Adducts</title><author>Amna Kamal, Amna Kamal ; Muhammad Adnan Iqbal, Muhammad Adnan Iqbal ; Haq Nawaz Bhatti and Abdul Ghaffar, Haq Nawaz Bhatti and Abdul Ghaffar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-4ceeaa30d19c78deb52338c1ae7bc0bb02827ebb5151c9524a7db790de87f4e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Carbenes</topic><topic>Chemical synthesis</topic><topic>Heterocyclic compounds</topic><topic>Identification and classification</topic><topic>Methods</topic><topic>Properties</topic><topic>Selenium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amna Kamal, Amna Kamal</creatorcontrib><creatorcontrib>Muhammad Adnan Iqbal, Muhammad Adnan Iqbal</creatorcontrib><creatorcontrib>Haq Nawaz Bhatti and Abdul Ghaffar, Haq Nawaz Bhatti and Abdul Ghaffar</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of the Chemical Society of Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amna Kamal, Amna Kamal</au><au>Muhammad Adnan Iqbal, Muhammad Adnan Iqbal</au><au>Haq Nawaz Bhatti and Abdul Ghaffar, Haq Nawaz Bhatti and Abdul Ghaffar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic, Thrombolytic and Antibacterial Evaluation of Synthesized Substituted and Un-Substituted Selenium-N-Heterocyclic Carbene Adducts</atitle><jtitle>Journal of the Chemical Society of Pakistan</jtitle><date>2023-02-28</date><risdate>2023</risdate><volume>45</volume><issue>1</issue><spage>44</spage><epage>44</epage><pages>44-44</pages><issn>0253-5106</issn><abstract>Alkyl-substituted azolium salts (1-8) and their Se-N-heterocyclic carbene (Se-N-Het-C) adducts (9-12) were obtained in very reasonable yields.
All synthesized azolium salts and their Se-N-Het-C adducts were characterized by different spectroscopic techniques such as FT-IR, 1HNMR, 13CNMR, and elemental analysis. It was found that all synthesized Se-N-Het-C adducts were stable at room temperature in both air and moisture. In-vitro these compounds (5-12) were assessed for their antimicrobial potential against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis), and Bacillus cereus (B. cereus) in vitro. Results of MIC and inhibition zone values revealed that the majority of the Selenium N-Heterocyclic carbene adducts were active against Bacillus subtilis (B. subtilis) than Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) whereas opposite in the azolium salts (5-8). Compounds 5-8 have an inhibition zone of 16and#177;0.1-26and#177;0.3mm against all tested bacterial strains while selenium-NHC adducts 9-12 have a zone of inhibition (16and#177;0.2 to 25 and#177; 0.4mm). Adduct 12 showed good activity against all tested strains with ZI values 25 and#177; 0.1, 22and#177; 0.5, 17 and#177; 0.3 mm and MIC values 17 and#177; 0.2, 16 and#177; 0.4 and 18 and#177; 0.3 and#181;g/mL against Bacillus subtilis (B. subtilis), Macrococcus brunensis (M. brunensis) and Bacillus cereus (B. cereus) respectively. Adduct 10 showed the highest thrombolysis i-e 86.9% and adduct 12 showed good hemolysis i-e 0.51%. Overall results of thrombolysis and cytotoxicity studies revealed that the compounds are safe for preclinical studies of mouse blood in vitro.</abstract><pub>Knowledge Bylanes</pub><doi>10.52568/001198/JCSP/45.01.2023</doi><tpages>1</tpages></addata></record> |
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subjects | Analysis Carbenes Chemical synthesis Heterocyclic compounds Identification and classification Methods Properties Selenium |
title | Cytotoxic, Thrombolytic and Antibacterial Evaluation of Synthesized Substituted and Un-Substituted Selenium-N-Heterocyclic Carbene Adducts |
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