Value of 3D ultrasound flow imaging combined with serum AFP, [beta]-hCG, sFlt-1 and CK in the diagnosis of placenta accreta

Purpose To analyze the diagnostic value of placenta three-dimensional (3D) energy blood flow parameters combined with maternal serum AFP, [beta]-hCG, sFlt-1 and CK levels for PA. Methods 30 pregnant women with PA and 30 pregnant women with normal placenta were randomly selected in the Affiliated Mat...

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Bibliographic Details
Published in:BMC women's health 2022-12, Vol.22 (1)
Main Authors: Cai, Sheng-nan, Wu, Yan-ting, Zeng, Li, Ding, Yi-qian
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Diagnosis
Health aspects
Methods
Patient outcomes
Placenta accreta
Pregnant women
Prenatal diagnosis
Serodiagnosis
Ultrasound imaging
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Summary:Purpose To analyze the diagnostic value of placenta three-dimensional (3D) energy blood flow parameters combined with maternal serum AFP, [beta]-hCG, sFlt-1 and CK levels for PA. Methods 30 pregnant women with PA and 30 pregnant women with normal placenta were randomly selected in the Affiliated Maternal and Child Health Hospital of Nantong University from January 2021 to December 2021. Thereafter, the 3D energy ultrasound was applied to detect the placenta VI, FI and VFI. Moreover, the diagnostic value of different parameters combined with serum AFP, [beta]-hCG, sFlt-1 and CK levels for PA was analyzed. Results Multivariate analysis results indicated that, gravidity > 2 and with/without placenta previa were the independent risk factors for PA (P < 0.05). In PA group, the AFP, [beta]-hCG, CK, placenta VI, FI and VFI values were higher than those in non-PA group, while sFlt-1 was apparently lower than that in non-PA group. With the increase in PA degree, the serum AFP, [beta]-hCG and CK levels increased. Meanwhile, serum sFlt-1 level was negatively correlated with PA degree. Serum AFP, [beta]-hCG, sFlt-1, CK and placenta VFI showed prediction potency for PA, and their combined detection attained the optimal diagnostic value for predicting PA. ROC curve analysis suggested that, serum AFP, [beta]-hCG, sFlt-1, CK and 3D ultrasound VFI value had the greatest AUC values in predicting PA, which might provide reference for the clinical diagnosis and disease evaluation of PA. Conclusion Serum AFP, [beta]-hCG, sFlt-1, CK and placental VFI can increase the consistency in the diagnosis of PA. Serum markers combined with 3D ultrasound blood flow imaging can improve the sensitivity and specificity of prenatal diagnosis of PA, which provides an important reference for clinical diagnosis and treatment. Keywords: Placenta accrete, AFP, [beta]-hCG, sFlt-1, CK, Three-dimensional ultrasound, Combined prediction, Diagnostic value
ISSN:1472-6874
1472-6874
DOI:10.1186/s12905-022-02107-z