novel AAT-deletion mutation in the coding sequence of the BCO2 gene in yellow-fat rabbits

The carcasses of yellow-fat rabbits may be attractive to modern consumers, because they have a relatively high content of biologically active compounds. One of the main candidate genes associated with the yellow-fat trait is β-carotene 9′,10′-oxygenase (BCO2). This study is the first report of the n...

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Bibliographic Details
Published in:Journal of applied genetics 2015-11, Vol.56 (4), p.535-537
Main Authors: Strychalski, Janusz, Brym, Paweł, Czarnik, Urszula, Gugołek, Andrzej
Format: Article
Language:English
Subjects:
Animal genetics
Animal Genetics and Genomics
Animal Genetics • Short Communication
Beta carotene
Biomedical and Life Sciences
Codon
Genes
Genetic aspects
Genetic polymorphisms
Genetic research
Human Genetics
Life Sciences
Microbial Genetics and Genomics
Plant Genetics and Genomics
Wildlife conservation
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Summary:The carcasses of yellow-fat rabbits may be attractive to modern consumers, because they have a relatively high content of biologically active compounds. One of the main candidate genes associated with the yellow-fat trait is β-carotene 9′,10′-oxygenase (BCO2). This study is the first report of the novel AAT-deletion mutation at codon 248 of the BCO2 gene, which has been found in homozygous yellow-fat rabbits. The deletion mutation, located at the beginning of exon 6, results in the absence of asparagine in protein. We also developed a PCR-RFLP test that supports intravital genotyping of indel polymorphism based on genomic DNA.
ISSN:1234-1983
2190-3883
DOI:10.1007/s13353-015-0290-9