Developing centrifugal spun thermally cross-linked gelatine based fibrous biomats for antibacterial wound dressing applications

Fibrous materials obtained from natural polymers, such as gelatin, have been used in medical applications due to their biocompatibility and biodegradability. Herein, free-standing durable fibrous gelatin biomats with antibacterial activity were developed via a simple, low cost and fast production ro...

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Bibliographic Details
Published in:Polymer engineering and science 2021-09, Vol.61 (9), p.2311
Main Authors: Gungor, Melike, Sagirli, Merve Nur, Calisir, Mehmet Durmus, Selcuk, Sule, Kilic, Ali
Format: Article
Language:English
Subjects:
Analysis
Biomedical materials
Biopolymers
Care and treatment
Composition
Permeability
Wounds and injuries
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Summary:Fibrous materials obtained from natural polymers, such as gelatin, have been used in medical applications due to their biocompatibility and biodegradability. Herein, free-standing durable fibrous gelatin biomats with antibacterial activity were developed via a simple, low cost and fast production route, centrifugal spinning, and subsequent thermal crosslinking. After a series of preliminary experiments, droplet-/bead-free porous biomats with fine fibers, 3.41 [+ or -] 1.8 [micro]m in diameter, were fabricated. Subsequently, antimicrobial biomats were produced by adding AgN[O.sub.3] into the production solution. X-ray diffractometer and energy dispersive X-ray results showed Ag NPs existing as AgCl in the biomats, which could be attributed to chemical reaction between the Ag NPs and residual CI in the impure gelatin. Later, both the neat-gelatin and Ag-gelatin biomats were thermally crosslinked at 170[degrees]C to gain stability against water. Although the Ag addition reduced ultimate tensile strength by half, from 881 to 495 kPa, the crosslinked biomats were robust enough to be used for wound dressing applications. They were also found to be highly breathable, with the air permeability of 256 and 81.2 mm/s, respectively. The biomats showed antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. The results show that the free-standing fibrous-gelatinbased biomats produced is applicable for wound dressing applications.
ISSN:0032-3888
1548-2634
DOI:10.1002/pen.25759