Frequency of Anti-HCV, HBsAg, HIV1-p24 Antigen, Acid Fast Bacilli and Plasmodium spp., in Herbal Home and Hospital Patients with Elevated TNF[alpha] in Saki, West Nigeria

Infectious agents and chemical substances can trigger the production and the release of cytokines. To determine the pattern of infectious agents in herbal homes patients with elevated TNF[alpha] ([greater than or equal to] 5.0 pg/ml) in Saki--West-Nigeria. The subjects include patients with elevated...

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Bibliographic Details
Published in:Journal of pure & applied microbiology : an international research journal of microbiology 2019-06, Vol.13 (2), p.841
Main Authors: Olaniyan, Mathew Folaranmi, Azeez, Mufutau M
Format: Article
Language:English
Subjects:
Antigens
Enzyme-linked immunosorbent assay
Hepatitis C virus
Hospital patients
Tumor necrosis factor
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Summary:Infectious agents and chemical substances can trigger the production and the release of cytokines. To determine the pattern of infectious agents in herbal homes patients with elevated TNF[alpha] ([greater than or equal to] 5.0 pg/ml) in Saki--West-Nigeria. The subjects include patients with elevated TNF[alpha] ([greater than or equal to] 5.0 pg/ml) in 15 herbal homes(n=23 ; aged 5-69 years; males--13 ; females--10) and patients with elevated TNF[alpha] in 3 major hospitals (n = 32; aged 6 -67years; males--12; females--20). Plasma TNF[alpha], anti-HCV, HBsAg and HIV1-p24 antigen were determined by ELISA, Plasmodium spp., by Giemsa thick film staining and Acid Fast Bacilli by Ziehl-Nelson staining. The frequency of infectious agents obtained in the patients include 4.3 anti-HCV; 17.4% (4) HBsAg; 4.3 %(1) HIV1-p24 antigen; 17.4% (4) Plasmodium spp.; 8.7 %(2) Acid Fast Bacilli and 4.3 HBsAg + Plasmodium spp., in patients of herbal homes and 6.3 %(2) anti-HCV; 9.4% (3) HBsAg; 3.1 HIV1-p24 antigen; 15.6% (6) Plasmodium spp., 0%(0) Acid Fast Bacilli and 3.1 HBsAg + Plasmodium spp., in patients of the three major hospitals. The frequency of those with 5.0 - 6,0 pg/ml TNF[alpha] (65.2% (15)) was more than those whose TNFa was between 6.1 -6.8 pg/ml (34.8% (8) in herbal home patients while the frequency of those with 5.0 - 6,0 pg/ml TNF[alpha] (40.6%(13)) was lower than those whose TNF[alpha] was between 6.1 - 6.8 pg/ml (59.4% (19)) in hospital patients. The pattern of the infectious agents was more in herbal home patients with 5.0 - 6,0 pg/ml TNF[alpha] than those with 6.1 - 6, 8 pg/ml TNF[alpha] while in hospital patients it was more in those with 6.1 - 6,8 pg/ml TNF[alpha] than those with 5.0 - 6,0 pg/ml TNF[alpha]. The overall frequency of the infectious agents was more in herbal homes patients (58.5%(13)) than 37.5%(12) obtained in hospital patients. The frequency of viral immunochemical biomarkers, Acid Fast Bacilli and Plasmodium spp., was more in herbal home patients than the patients recruited from the hospital which varies with the TNF[alpha] range. Keywords: Anti-HCV, HBsAg, HIV1-p24 antigen, Acid Fast Bacilli, Plasmodium spp., herbal homes patients, elevated TNF[alpha].
ISSN:0973-7510
DOI:10.22207/JPAM.13.2.19