Nootropic and Neuroprotective Effects of Ethanol Extract of Hibiscus Sabdariffa L. on ScopolamineInduced Cognitive Deficit in Mice

The aim of this investigation was to explore the neuroprotective and memory-enhancing effect of Hibiscus sabdariffa L. ethanolic extract on scopolamine-induced learning and memory deficit in young mice. The nootropic and neuroprotective potential of the extract in scopolamine induced amnesic mice wa...

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Bibliographic Details
Published in:Current topics in nutraceuticals research 2021-08, Vol.19 (3), p.345
Main Authors: Alshabi, Ali Mohamed, Shaikh, Ibrahim Ahmed, Habeeb, Mohammed Shafiuddin
Format: Article
Language:English
Subjects:
Acetaldehyde
Alcohol
Alcohol, Denatured
Alzheimer's disease
Brain
Interleukins
Nervous system diseases
Scopolamine
Transforming growth factors
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Summary:The aim of this investigation was to explore the neuroprotective and memory-enhancing effect of Hibiscus sabdariffa L. ethanolic extract on scopolamine-induced learning and memory deficit in young mice. The nootropic and neuroprotective potential of the extract in scopolamine induced amnesic mice was evaluated by elevated plus maze, step-down avoidance, and Morris water maze tests after 14 days of daily administration. The extract significantly enhanced learning, memory function, improved spatial recognition, as well as successfully reversed scopolamine-induced amnesia. Also, it significantly decreased the brain acetylcholinesterase activity and optimized brain catecholamine levels. Histopathological results confirmed the protective effect of the extract on hippocampal and cortical neurons. These findings suggest that ethanolic extract of H. sabdariffa can confer neuroprotection and augment memory. In conclusion, H. sabdariffa can be used in the management of amnesia and neurodegenerative diseases involving learning, memory, and cognitive dysfunctions. Keywords: Alzheimer's disease, Cholinergic deficit, Hibiscus sabdariffa, Neuroprotective, Phytochemicals Abbreviations Used: Acetylcholinesterase, AChE; Alzheimer's disease, AD; Analysis of variance, ANOVA; Dopamine, DA; Escape Latency Time, ELT; Elevated plus maze, EPM; Gallic acid equivalent, GAE; High-performance thin-layer chromatography, HPTLC; Hibiscus Sabdariffa ethanol extract, HSE; Interleukin-6, IL-6; Interleukin-12, IL-12; Interleukin-17, IL-17; Interleukin-18, IL-18; Interleukin-1 [beta], IL-1[beta]; Interleukin-23, IL-23; Morris water maze, MWM; Noradrenaline, NA; Step-down-type passive shock avoidance, PSA; Scopolamine, SCO; Step-down latency, SDL; Standard error of mean, SEM; Transforming growth factor beta, TGF-p; Transfer latency time, TL; Tumor necrosis factor alpha, TNF-[alpha] Corresponding Author: Dr. Ali Mohamed Alshabi, Vice Dean, Academic Affairs, Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia; E-mail: dr.aliresearch19@gmail.com
ISSN:1540-7535
2641-452X
DOI:10.37290/ctnr2641-452X.19:345-352