Congenital hepatic fibrosis associated with ascites in a nellore calf/ Fibrose hepatica congenita associada a ascite em um bezerro nelore

Congenital hepatic fibrosis (CHF) is an autosomal recessive malformation characterized by a variable degree of fibrosis and bile duct proliferation, mainly described in people and rarely reported in bovine European breeds. In addition to liver fibrosis, this syndrome has been associated with ascites...

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Published in:Ciência rural 2020-05, Vol.50 (5)
Main Authors: de Gois, Daniela Dantas, de Sousa, Isabelle Vieira, Barbosa, Francisca Maria Sousa, Neto, Jose Ferreira da Silva, Sampaio, Rubia Avlade Guedes, Simoes, Sara Vilar Dantas, Dantas, Igor Mariz, Lucena, Ricardo Barbosa
Format: Article
Language:English
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Summary:Congenital hepatic fibrosis (CHF) is an autosomal recessive malformation characterized by a variable degree of fibrosis and bile duct proliferation, mainly described in people and rarely reported in bovine European breeds. In addition to liver fibrosis, this syndrome has been associated with ascites and subcutaneous edema in calves. This paper described the pathological findings of the first report of CHF in a Nelore bovine fetus. A stillborn calf was removed by cesarean section because of dystocia. At necropsy, characteristic changes of CHF were observed, such as a large increase in abdominal volume associated with hepatic fibrosis and marked subcutaneous edema. Histological examination of liver revealed periportal and port-portal islands of fibrosis separating the parenchyma into nodules of variable sizes and containing numerous abnormally shaped bile ducts. The CHF should be considered in the differential diagnosis in young calves that present with ascites. Key words: Bos primigenius indicus, genetic factors, malformation, perinatal mortality. A fibrose hepatica congenita (FHC) e uma malformacao autossomica recessiva, caracterizada por um variavel grau de fibrose e proliferacao de ductos biliares, descrita principalmente em pessoas, e raramente relatada em bovinos de racas europeias. Alem da fibrose hepatica em bezerros, esta sindrome tem sido associada a ascite e edema subcutaneo. O presente trabalho apresenta os achados anatomopatologicos do primeiro relato de FHC em um feto bovino da raca nelore. O bezerro natimorto foi retirado por meio de cesariana devido a distocia. Na necropsia foram verificadas alteracoes caracteristicas da FHC, como grande aumento de volume abdominal associado a fibrose hepatica e marcado edema subcutaneo. O exame histologico do figado revelou ilhas de fibrose periportal e porto-portal, separando o parenquima em nodulos de tamanhos variaveis e contendo numerosos ductos biliares irregulares de tamanhos anormais. Palavras-chave: Bos primigenius indicus, fatores geneticos, malformacao, mortalidade perinatal.
ISSN:0103-8478
1678-4596
DOI:10.1590/0103-8478cr20190511