Electrocardiographic Alterations in Patients with Common Variable Immune Deficiency/Yaygin Degisken immun Yetmezligi Olan Hastalarda Elektrokardiyografik Degisikliklerin Degerlendirilmesi

Introduction: Common variable immunodeficiency (CVID) is the most heterogeneous group among the antibody deficiency syndromes, but its effects on the cardiovascular system have not yet been clearly identified. Here, we aimed to investigate the arrhythmogenic effects of this disease with electrocardi...

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Bibliographic Details
Published in:Istanbul medical journal 2020-03, Vol.21 (2), p.109
Main Authors: Alsancak, Yakup, Colkesen, Fatih
Format: Article
Language:eng ; tur
Subjects:
Antibodies
Arrhythmia
Care and treatment
Comorbidity
Comparative analysis
Diseases
Electrocardiogram
Electrocardiography
Immunologic deficiency syndromes
Medical research
Medicine, Experimental
Public relations
Viral antibodies
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Summary:Introduction: Common variable immunodeficiency (CVID) is the most heterogeneous group among the antibody deficiency syndromes, but its effects on the cardiovascular system have not yet been clearly identified. Here, we aimed to investigate the arrhythmogenic effects of this disease with electrocardiography. Methods: The study included 30 CVID patients and 30 control subjects matched for age and comorbidities. Electrocardiographic and echocardiographic values of all participants were recorded. QRS, QT, Tp-e were measured manually. QTc was calculated using Bazett's formula. Then, Tp-e/QT, Tp-e/QTc, QT/QRS, and QTc/QRS ratios were calculated and compared between the groups. Results: PR interval and P-wave dispersion were found to be higher in the CVID group. In addition, the QT interval and corrected QT interval, T peak-to-end interval were higher in the CVID arm, and the index of cardiac electrophysiological balance valueobtained with the QT/QRS ratio was also higher in the CVID group. The number of patients with P terminal force was also higher in the CVID group. Conclusion: As a result of this study, it was found that CVID patients have a higher incidence of developing arrhythmia than normal healthy individuals. Keywords: Arrhythmia, CVID, electrocardiography Amac: Ortak degisken immun yetmezlik (CVID), antikor eksikligi sendromlari arasinda en heterojen gruptur, ancak kardiyovaskuler sistem uzerindeki etkileri henuz net bir sekilde tanimlanamamistir. Burada, bu hastaligin olasi aritmojenik etkilerini, elektrokardiyografi ile degerlendirmeyi amacladik. Yontemler: Calismaya 30 CVID hastasi ile yas ve komorbiditeleri eslesen 30 gonullu kontrol grubu dahil edildi. Tum katilimcilarin elektrokardiyografik ve ekokardiyografik degerleri kaydedildi. QRS, QT, Tp-e manuel olarak olculdu. QTc, Bazett formulu kullanilarak hesaplandi. Daha sonra, Tp-e/QT, Tp-e/QTc, QT/QRS ve QTc/QRS oranlari hesaplandi ve gruplar arasinda karsilastirilma yapildi. Bulgular: CVID grubunda PR araligi ve P dalga dispersiyonu daha yuksek bulundu. Ayrica, QT araligi ve duzeltilmis QT araligi, T peak-to-end interval, CVID kolunda daha yuksekti ve QT/QRS orani ile elde edilen kardiyak elektrofizyolojik denge indeksi degeri CVID grubunda da daha yuksekti. CVID grubunda P terminal kuvveti olan hasta sayisi da daha fazla idi. Sonuc: Bu calisma sonucunda, CVID hastalarinin normal saglikli bireylere gore aritmi gelisme sikliginin daha yuksek olabilecegi bulunmustur. Anahtar Kelimeler: Aritmi, CVID,
ISSN:2619-9793
1304-8503
DOI:10.4274/imj.galenos.2020.47855