Development of Compositions and Production Technology for Gels with a Solid Dispersal of Nitrofural

Compositions of gels with solid dispersions of nitrofural at a concentration of 0.04% were screened. Studies of the organoleptic properties, identity, assay of active ingredient, pH, and release led to selection of four compositions. The shelf life was determined (two years) and the storage conditio...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2020, Vol.53 (10), p.981-985
Main Authors: Belyatskaya, A. V., Kashlikova, I. M., Krasnyuk, I. I., Stepanova, O. I., Vorob’ev, A. N.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Povidone
Technology application
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Summary:Compositions of gels with solid dispersions of nitrofural at a concentration of 0.04% were screened. Studies of the organoleptic properties, identity, assay of active ingredient, pH, and release led to selection of four compositions. The shelf life was determined (two years) and the storage conditions for the gel compositions developed here were identified. The proposed production technology for gels with solid dispersals of nitrofural yielded stable compositions with an active ingredient concentration of 0.04%, providing higher levels of nitrofural release than the currently available 0.2% furacillin ointment due to greater solubility and a greater rate of dissolution of active ingredient.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-020-02109-x