Development and Optimization of Green Method for Antihistamine Using Ecofriendly Reagent in Pure and Pharmaceutical Formulations by Microwave Assisted Spectrophotometry

Synthetic substances and solvents utilized in investigation of drugs crumble the earth as well as human health. So attempts should be made to minimize or eliminate the utilization of obnoxious chemicals and solvents. The objective of study is to develop the green spectroscopic method using new ecofr...

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Bibliographic Details
Published in:Journal of the Chemical Society of Pakistan 2019-12, Vol.41 (6), p.1028-1028
Main Authors: Amina Mumtaz, Amina Mumtaz, Sajjad ul Hassan and Shafaq Mubarak, Sajjad ul Hassan and Shafaq Mubarak
Format: Article
Language:English
Subjects:
Analysis
Desloratadine
Methods
Reagents
Sustainable development
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Summary:Synthetic substances and solvents utilized in investigation of drugs crumble the earth as well as human health. So attempts should be made to minimize or eliminate the utilization of obnoxious chemicals and solvents. The objective of study is to develop the green spectroscopic method using new ecofriendly chromogenic reagent for the evaluation of antihistamine i.e. desloratadine in pure and commercial dosage forms. Both heating systems (conventional and microwave assisted procedures) are used for the development of color. The method is based on formation of stable blue coloured complex with ammonium molybdate in the presence of acid having λmax at 732nm respectively. All the reaction conditions and different statistic parameters for the proposed methods have been studied. The method is found to be rapid, precise and accurate and can be successfully used for the determination of antihistamines in bulk and commercial tablet formulations.
ISSN:0253-5106
DOI:10.52568/000810/JCSP/41.06.2019