Prognostic significance of progranulin and B7-H4 in patients with diffuse large B-cell lymphoma

Background Progranulin (PGRN) plays a substantial role in tumorigenesis, and its serum level is increased in many types of human cancers. Moreover, B7-H4 plays a remarkable role in regulation of the tumor microenvironment. It is overexpressed in different types of human cancers, and dysregulation of...

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Published in:The Egyptian journal of haematology : the official journal of the Egyptian Society of Haematology 2019-04, Vol.44 (2), p.82-90
Main Authors: Elkholy, Rasha, Allam, Alzahraa, Elattar, Shimaa, Elkady, Asmaa
Format: Article
Language:English
Subjects:
Care and treatment
Development and progression
Non-Hodgkin's lymphomas
Prognosis
Vincristine
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Summary:Background Progranulin (PGRN) plays a substantial role in tumorigenesis, and its serum level is increased in many types of human cancers. Moreover, B7-H4 plays a remarkable role in regulation of the tumor microenvironment. It is overexpressed in different types of human cancers, and dysregulation of its expression has been associated with tumor progression. Aim This study aimed to estimate serum levels of PGRN and B7-H4 in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) and their relation to patient prognosis and survival. Patients and methods This case-control study was performed on 50 patients with newly diagnosed DLBCL and 30 apparently healthy individuals as a control group. Enzyme-linked immunosorbent assay was used to measure serum levels of PGRN and B7-H4. Results This study revealed that serum levels of PGRN and B7-H4 were higher in patients with DLBCL compared with the control group. Receiver operating curve analysis showed that serum PGRN at a cutoff value of greater than 98 ng/ml had a sensitivity of 80% and a specificity of 93.33%, and serum B7-H4 at a cutoff value of greater than 49 ng/ml had a sensitivity of 70% and a specificity of 96.67% for DLBCL diagnosis. In patients with DLBCL, progression-free survival and overall survival significantly decreased with increased serum levels of PGRN and B7-H4 above the cutoff levels. Conclusion PGRN and B7-H4 can be useful in determining prognosis of patients with DLBCL.
ISSN:1110-1067
2090-9268
DOI:10.4103/ejh.ejh_16_19