Color coded perfusion imaging with contrast enhanced ultrasound of hepatocellular carcinoma

Aim Evaluation of an external color coded perfusion quantification software with CEUS for the post-interventional success control following TACE in patients with HCC. Material and methods 31 patients (5 females, 26 males, age range 34-82 years, mean 66.8 years) with 59 HCC lesions underwent supersel...

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Bibliographic Details
Published in:PloS one 2019-06, Vol.14 (6), p.e0217599
Main Authors: Rennert, Janine, Wiesinger, Isabel, Schicho, Andreas, Beyer, Lukas Philip, Wiggermann, Philipp, Stroszczynski, Christian, Jung, Ernst Michael
Format: Article
Language:English
Subjects:
Cancer
Carcinoma
Care and treatment
Diagnostic ultrasonography
Hepatocellular carcinoma
Liver
Magnetic resonance imaging
Sorafenib
Therapeutic embolization
Tumors
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Summary:Aim Evaluation of an external color coded perfusion quantification software with CEUS for the post-interventional success control following TACE in patients with HCC. Material and methods 31 patients (5 females, 26 males, age range 34-82 years, mean 66.8 years) with 59 HCC lesions underwent superselective TACE using DSM Beads between 01/2015 and 06/2018. All patients underwent CEUS by an experienced examiner using a convex multifrequency probe (1-6 MHz) within 24 hours following TACE to detect residual tumor tissue. Retrospective evaluation using a perfusion quantification software regarding pE, TTP, mTT, Ri and WiAUC in the center of the lesion, the margin and surrounding liver. Results In all lesions, a post-interventional visual reduction of the tumor microvascularization was observed. Significant differences between center of the lesion vs. margin and surrounding liver were found regarding peak enhancement (867.8 ± 2416 center vs 2028 ± 3954 margin p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0217599