Association between COMT Vall 58Met and DATI polymorphisms and depressive symptoms in the obese population

Objectives: Depressive symptoms are common among patients with obesity. Abnormalities in dopamine signaling involved in the reward circuit may ensue excessive consumption of food, resulting in obesity and leading to neuropsychiatric disorders such as depression. This study sought to investigate the...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2017-01, Vol.13, p.2221
Main Authors: Bielinski, Maciej, Jaracz, Marcin, Lesiewska, Natalia, Tomaszewska, Marta, Sikora, Marcin, Junik, Roman, Kaminska, Anna, Tretyn, Andrzej, Borkowska, Alina
Format: Article
Language:English
Subjects:
Depression (Mood disorder)
Genetic aspects
Genetic polymorphisms
Nervous system diseases
Obesity
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Summary:Objectives: Depressive symptoms are common among patients with obesity. Abnormalities in dopamine signaling involved in the reward circuit may ensue excessive consumption of food, resulting in obesity and leading to neuropsychiatric disorders such as depression. This study sought to investigate the association of polymorphisms in the genes encoding DAT1/SLC6A3 and COMT with the intensity of depressive symptoms in obese subjects. Participants and methods: Prevalence and severity of depressive symptoms were assessed in a group of 364 obese patients using the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale (HDRS). Genetic polymorphisms in DAT1 and COMT were evaluated in peripheral blood samples. Results: The results indicated an association between DAT1 alleles and depressive symptoms, as well as severity of obesity. Subjects homozygous for the nine-repeat allele scored higher in BDI (P=0.022) and HDRS (P=0.00001), suggesting higher intensity of depression in both sexes. This allele was also associated with the highest body mass index (BMI; P=0.001). Carriers of the Val158Met allele of COMT scored higher on both depression scales (BDI, P=0.0005; HRDS, P=0.002) and had the highest BMI values. Conclusion: Polymorphisms in the DAT1 and COMT genes are associated with a greater intensity of depressive symptoms in the obese population. Keywords: dopaminergic signaling, obesity, depressive symptoms, reward circuit, gene polymorphism
ISSN:1176-6328
1178-2021
DOI:10.2147/NDT.S138565