The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats 1

Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvas...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2017-11, Vol.95 (11), p.1343
Main Authors: Vranic, Aleksandra, Simovic, Stefan, Ristic, Petar, Nikolic, Tamara, Stojic, Isidora, Srejovic, Ivan, Zivkovic, Vladimir, Jakovljevic, Vladimir, Djuric, Dusan
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Complications and side effects
Dosage and administration
Patient outcomes
Physiological aspects
Spironolactone
Streptozocin
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Summary:Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 [micro]mol/L of spironolactone, diabetic rats treated with 0.1 [micro]mol/L of spironolactone, healthy rats treated with 3 p.mol/L of spironolactone, and diabetic rats treated with 3 [micro],mol/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed.
ISSN:0008-4212
DOI:10.1139/cjpp-2017-0055