T Cell Responses to the RTS,S/AS01.sub.E and RTS,S/AS02.sub.D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01.sub.E or the oil-in-water based adjuvant AS02.sub.D induces P. falciparum circums...

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Bibliographic Details
Published in:PloS one 2011-04, Vol.6 (4), p.e18891
Main Authors: Ansong, Daniel, Asante, Kwaku P, Vekemans, Johan, Owusu, Sandra K, Owusu, Ruth, Brobby, Naana A. W, Dosoo, David, Osei-Akoto, Alex, Osei-Kwakye, Kingsley, Asafo-Adjei, Emmanuel, Boahen, Kwadwo O, Sylverken, Justice, Adjei, George, Sambian, David, Apanga, Stephen, Kayan, Kingsley, Janssens, Michel H, Lievens, Marc J. J, Olivier, Aurelie C, Jongert, Erik, Dubois, Patrice, Savarese, Barbara M, Cohen, Joe, Antwi, Sampson, Greenwood, Brian M, Evans, Jennifer A, Agbenyega, Tsiri, Moris, Philippe J, Owusu-Agyei, Seth
Format: Article
Language:English
Subjects:
Analysis
Antigens
Malaria
Plasmodium falciparum
T cells
Vaccination
Vaccines
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Summary:The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01.sub.E or the oil-in-water based adjuvant AS02.sub.D induces P. falciparum circumsporozoite (CSP) antigen-specific antibody and T cell responses which have been associated with protection in the experimental malaria challenge model in adults. This study was designed to evaluate the safety and immunogenicity induced over a 19 month period by three vaccination schedules (0,1-, 0,1,2- and 0,1,7-month) of RTS,S/AS01.sub.E and RTS,S/AS02.sub.D in children aged 5-17 months in two research centers in Ghana. Control Rabies vaccine using the 0,1,2-month schedule was used in one of two study sites. Whole blood antigen stimulation followed by intra-cellular cytokine staining showed RTS,S/AS01.sub.E induced CSP specific CD4 T cells producing IL-2, TNF-[alpha], and IFN-[gamma]. Higher T cell responses were induced by a 0,1,7-month immunization schedule as compared with a 0,1- or 0,1,2-month schedule. RTS,S/AS01.sub.E induced higher CD4 T cell responses as compared to RTS,S/AS02.sub.D when given on a 0,1,7-month schedule. These findings support further Phase III evaluation of RTS,S/AS01.sub.E . The role of immune effectors and immunization schedules on vaccine protection are currently under evaluation.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0018891