Selection of Standardization Parameters and Development of Quality Control Methods for Isoleucyl-Tryptophan Dipeptide Coordination Complex with Iron(II) (Timofer)

The coordination complex of the dipeptide isoleucyl-tryptophan with Fe(II) possesses immunostimulating activity and is effective for treating iron- and immunodeficiency and pulmonary, rheumatological, and urological diseases. Results are presented from the development of quantitative assays for isol...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2016-12, Vol.50 (9), p.620-624
Main Authors: Bunyatyan, N. D., Kholnazarov, B. M., Olefir, Yu. V., Bobizoda, G. M.
Format: Article
Language:English
Subjects:
Backup software
Medical schools
Medicine
Methods
Organic Chemistry
Peptides
Pharmacology/Toxicology
Pharmacy
Quality control
Quality management
Tryptophan
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Summary:The coordination complex of the dipeptide isoleucyl-tryptophan with Fe(II) possesses immunostimulating activity and is effective for treating iron- and immunodeficiency and pulmonary, rheumatological, and urological diseases. Results are presented from the development of quantitative assays for isoleucyl-tryptophan– Fe(II) using the Fe(II) ion and the tryptophan indole moiety. The standardization parameters of a reference sample, drug substance, and its dosage form are determined.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1502-2