The Impact of HIF1[alpha] on the Per2 Circadian Rhythm in Renal Cancer Cell Lines

In mammals, the circadian rhythm central generator consists of interactions among clock genes, including Per1/2/3, Cry1/2, Bmal1, and Clock. Circadian rhythm disruption may lead to increased risk of cancer in humans, and deregulation of clock genes has been implicated in many types of cancers. Among...

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Bibliographic Details
Published in:PloS one 2014-10, Vol.9 (10)
Main Authors: Okabe, Takashi, Kumagai, Megumi, Nakajima, Yoshihiro, Shirotake, Suguru, Kodaira, Kiichiro, Oyama, Masafumi, Ueno, Munehisa, Ikeda, Masaaki
Format: Article
Language:English
Subjects:
Cancer
Cancer genetics
Health aspects
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Summary:In mammals, the circadian rhythm central generator consists of interactions among clock genes, including Per1/2/3, Cry1/2, Bmal1, and Clock. Circadian rhythm disruption may lead to increased risk of cancer in humans, and deregulation of clock genes has been implicated in many types of cancers. Among these genes, Per2 is reported to have tumor suppressor properties, but little is known about the correlation between Per2 and HIF, which is the main target of renal cell carcinoma (RCC) therapy. In this study, the rhythmic expression of the Per2 gene was not detectable in renal cancer cell lines, with the exception of Caki-2 cells. In Caki-2 cells, HIF1[alpha] increased the amplitude of Per2 oscillation by directly binding to the HIF-binding site located on the Per2 promoter. These results indicate that HIF1[alpha] may enhance the amplitude of the Per2 circadian rhythm.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0109693