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Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain
Purpose In a previous study using the tail-flick test, we found that intracerebroventricular administration of d -serine, an endogenous co-agonist at the glycine sites of N -methyl- d -aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present s...
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| Published in: | Journal of anesthesia 2014-04, Vol.28 (2), p.228-234 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c473t-1fa84f1dbebcb59abd4ebde368e5ce59ff0b4058ded49aab5193e89ecdc17d143 |
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| cites | cdi_FETCH-LOGICAL-c473t-1fa84f1dbebcb59abd4ebde368e5ce59ff0b4058ded49aab5193e89ecdc17d143 |
| container_end_page | 234 |
| container_issue | 2 |
| container_start_page | 228 |
| container_title | Journal of anesthesia |
| container_volume | 28 |
| creator | Ito, Miho Yoshikawa, Masanobu Ito, Kenji Matsuda, Mitsumasa Jin, Xing Lu Takahashi, Shigeru Kobayashi, Hiroyuki Suzuki, Toshiyasu |
| description | Purpose
In a previous study using the tail-flick test, we found that intracerebroventricular administration of
d
-serine, an endogenous co-agonist at the glycine sites of
N
-methyl-
d
-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the effect of intracerebroventricular administration of
d
-serine on nociception induced by tissue damage or inflammation using the formalin test.
Methods
Infusion of drugs into the third ventricle in rat was performed via indwelling cannulae. Drugs were infused at a volume of 10 μl over 2 min, and the infusion cannula was left in place for 2 min before removal. The formalin test was performed 10 min after drug administration.
Results
Intracerebroventricular administration of
d
-serine significantly and dose-dependently decreased the number of flinches in both the early and late phases in the formalin test. This antinociceptive effect was antagonized by intracerebroventricular administration of L-701,324, a selective antagonist at the glycine sites of NMDA receptors.
Conclusion
The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain. |
| doi_str_mv | 10.1007/s00540-013-1708-3 |
| format | article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A372958813</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A372958813</galeid><sourcerecordid>A372958813</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-1fa84f1dbebcb59abd4ebde368e5ce59ff0b4058ded49aab5193e89ecdc17d143</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxUVJSLZpP0AvxZCz0tFKtuXjEtKksNBLcxb6M1oUbGmRvIF--8g4LRSWModh9H5vYPQI-cLgjgH03wpAK4AC45T1ICn_QDZMcEklb4cLsoGhKrLr5DX5WMoLAHSM8StyvRUgZMdgQ3AX5xCTDRaPc3jFBr1HOzfJNyHOWVvMaHJ6xToEexp1brSbQgylinNIcSEdLZhDxKaOPuVJjyHSEN3JomuOOsRP5NLrseDn935Dnr8__Lp_ovufjz_ud3tqRc9nyryWwjNn0FjTDto4gcYh7yS2FtvBezACWunQiUFr07KBoxzQOst6Vy-_Ibfr3oMeUYXo03LCFIpVO95vh1ZKxitFz1AHjJj1mCL6UJ__4e_O8LUcTsGeNbDVYHMqJaNXxxwmnX8rBmpJTq3JqZqcWpJTi-fr6jmezITur-NPVBXYrkCpUjxgVi_plGP9zv9sfQP0AaXD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain</title><source>Springer Link</source><creator>Ito, Miho ; Yoshikawa, Masanobu ; Ito, Kenji ; Matsuda, Mitsumasa ; Jin, Xing Lu ; Takahashi, Shigeru ; Kobayashi, Hiroyuki ; Suzuki, Toshiyasu</creator><creatorcontrib>Ito, Miho ; Yoshikawa, Masanobu ; Ito, Kenji ; Matsuda, Mitsumasa ; Jin, Xing Lu ; Takahashi, Shigeru ; Kobayashi, Hiroyuki ; Suzuki, Toshiyasu</creatorcontrib><description>Purpose
In a previous study using the tail-flick test, we found that intracerebroventricular administration of
d
-serine, an endogenous co-agonist at the glycine sites of
N
-methyl-
d
-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the effect of intracerebroventricular administration of
d
-serine on nociception induced by tissue damage or inflammation using the formalin test.
Methods
Infusion of drugs into the third ventricle in rat was performed via indwelling cannulae. Drugs were infused at a volume of 10 μl over 2 min, and the infusion cannula was left in place for 2 min before removal. The formalin test was performed 10 min after drug administration.
Results
Intracerebroventricular administration of
d
-serine significantly and dose-dependently decreased the number of flinches in both the early and late phases in the formalin test. This antinociceptive effect was antagonized by intracerebroventricular administration of L-701,324, a selective antagonist at the glycine sites of NMDA receptors.
Conclusion
The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain.</description><identifier>ISSN: 0913-8668</identifier><identifier>EISSN: 1438-8359</identifier><identifier>DOI: 10.1007/s00540-013-1708-3</identifier><identifier>PMID: 24048610</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Analgesics - administration & dosage ; Analgesics - therapeutic use ; Anesthesiology ; Animals ; Critical Care Medicine ; Drug therapy ; Emergency Medicine ; Formaldehyde ; Health aspects ; Infusions, Intraventricular ; Intensive ; Male ; Medicine ; Medicine & Public Health ; Nociception ; Original Article ; Pain ; Pain - chemically induced ; Pain - drug therapy ; Pain Measurement - drug effects ; Pain Medicine ; Quinolones - administration & dosage ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate - agonists ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Serine ; Serine - administration & dosage ; Serine - therapeutic use</subject><ispartof>Journal of anesthesia, 2014-04, Vol.28 (2), p.228-234</ispartof><rights>Japanese Society of Anesthesiologists 2013</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-1fa84f1dbebcb59abd4ebde368e5ce59ff0b4058ded49aab5193e89ecdc17d143</citedby><cites>FETCH-LOGICAL-c473t-1fa84f1dbebcb59abd4ebde368e5ce59ff0b4058ded49aab5193e89ecdc17d143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24048610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Miho</creatorcontrib><creatorcontrib>Yoshikawa, Masanobu</creatorcontrib><creatorcontrib>Ito, Kenji</creatorcontrib><creatorcontrib>Matsuda, Mitsumasa</creatorcontrib><creatorcontrib>Jin, Xing Lu</creatorcontrib><creatorcontrib>Takahashi, Shigeru</creatorcontrib><creatorcontrib>Kobayashi, Hiroyuki</creatorcontrib><creatorcontrib>Suzuki, Toshiyasu</creatorcontrib><title>Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain</title><title>Journal of anesthesia</title><addtitle>J Anesth</addtitle><addtitle>J Anesth</addtitle><description>Purpose
In a previous study using the tail-flick test, we found that intracerebroventricular administration of
d
-serine, an endogenous co-agonist at the glycine sites of
N
-methyl-
d
-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the effect of intracerebroventricular administration of
d
-serine on nociception induced by tissue damage or inflammation using the formalin test.
Methods
Infusion of drugs into the third ventricle in rat was performed via indwelling cannulae. Drugs were infused at a volume of 10 μl over 2 min, and the infusion cannula was left in place for 2 min before removal. The formalin test was performed 10 min after drug administration.
Results
Intracerebroventricular administration of
d
-serine significantly and dose-dependently decreased the number of flinches in both the early and late phases in the formalin test. This antinociceptive effect was antagonized by intracerebroventricular administration of L-701,324, a selective antagonist at the glycine sites of NMDA receptors.
Conclusion
The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain.</description><subject>Analgesics - administration & dosage</subject><subject>Analgesics - therapeutic use</subject><subject>Anesthesiology</subject><subject>Animals</subject><subject>Critical Care Medicine</subject><subject>Drug therapy</subject><subject>Emergency Medicine</subject><subject>Formaldehyde</subject><subject>Health aspects</subject><subject>Infusions, Intraventricular</subject><subject>Intensive</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nociception</subject><subject>Original Article</subject><subject>Pain</subject><subject>Pain - chemically induced</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement - drug effects</subject><subject>Pain Medicine</subject><subject>Quinolones - administration & dosage</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, N-Methyl-D-Aspartate - agonists</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Serine</subject><subject>Serine - administration & dosage</subject><subject>Serine - therapeutic use</subject><issn>0913-8668</issn><issn>1438-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kU9r3DAQxUVJSLZpP0AvxZCz0tFKtuXjEtKksNBLcxb6M1oUbGmRvIF--8g4LRSWModh9H5vYPQI-cLgjgH03wpAK4AC45T1ICn_QDZMcEklb4cLsoGhKrLr5DX5WMoLAHSM8StyvRUgZMdgQ3AX5xCTDRaPc3jFBr1HOzfJNyHOWVvMaHJ6xToEexp1brSbQgylinNIcSEdLZhDxKaOPuVJjyHSEN3JomuOOsRP5NLrseDn935Dnr8__Lp_ovufjz_ud3tqRc9nyryWwjNn0FjTDto4gcYh7yS2FtvBezACWunQiUFr07KBoxzQOst6Vy-_Ibfr3oMeUYXo03LCFIpVO95vh1ZKxitFz1AHjJj1mCL6UJ__4e_O8LUcTsGeNbDVYHMqJaNXxxwmnX8rBmpJTq3JqZqcWpJTi-fr6jmezITur-NPVBXYrkCpUjxgVi_plGP9zv9sfQP0AaXD</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Ito, Miho</creator><creator>Yoshikawa, Masanobu</creator><creator>Ito, Kenji</creator><creator>Matsuda, Mitsumasa</creator><creator>Jin, Xing Lu</creator><creator>Takahashi, Shigeru</creator><creator>Kobayashi, Hiroyuki</creator><creator>Suzuki, Toshiyasu</creator><general>Springer Japan</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20140401</creationdate><title>Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain</title><author>Ito, Miho ; Yoshikawa, Masanobu ; Ito, Kenji ; Matsuda, Mitsumasa ; Jin, Xing Lu ; Takahashi, Shigeru ; Kobayashi, Hiroyuki ; Suzuki, Toshiyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-1fa84f1dbebcb59abd4ebde368e5ce59ff0b4058ded49aab5193e89ecdc17d143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analgesics - administration & dosage</topic><topic>Analgesics - therapeutic use</topic><topic>Anesthesiology</topic><topic>Animals</topic><topic>Critical Care Medicine</topic><topic>Drug therapy</topic><topic>Emergency Medicine</topic><topic>Formaldehyde</topic><topic>Health aspects</topic><topic>Infusions, Intraventricular</topic><topic>Intensive</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nociception</topic><topic>Original Article</topic><topic>Pain</topic><topic>Pain - chemically induced</topic><topic>Pain - drug therapy</topic><topic>Pain Measurement - drug effects</topic><topic>Pain Medicine</topic><topic>Quinolones - administration & dosage</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, N-Methyl-D-Aspartate - agonists</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Serine</topic><topic>Serine - administration & dosage</topic><topic>Serine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Miho</creatorcontrib><creatorcontrib>Yoshikawa, Masanobu</creatorcontrib><creatorcontrib>Ito, Kenji</creatorcontrib><creatorcontrib>Matsuda, Mitsumasa</creatorcontrib><creatorcontrib>Jin, Xing Lu</creatorcontrib><creatorcontrib>Takahashi, Shigeru</creatorcontrib><creatorcontrib>Kobayashi, Hiroyuki</creatorcontrib><creatorcontrib>Suzuki, Toshiyasu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Miho</au><au>Yoshikawa, Masanobu</au><au>Ito, Kenji</au><au>Matsuda, Mitsumasa</au><au>Jin, Xing Lu</au><au>Takahashi, Shigeru</au><au>Kobayashi, Hiroyuki</au><au>Suzuki, Toshiyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain</atitle><jtitle>Journal of anesthesia</jtitle><stitle>J Anesth</stitle><addtitle>J Anesth</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>28</volume><issue>2</issue><spage>228</spage><epage>234</epage><pages>228-234</pages><issn>0913-8668</issn><eissn>1438-8359</eissn><abstract>Purpose
In a previous study using the tail-flick test, we found that intracerebroventricular administration of
d
-serine, an endogenous co-agonist at the glycine sites of
N
-methyl-
d
-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the effect of intracerebroventricular administration of
d
-serine on nociception induced by tissue damage or inflammation using the formalin test.
Methods
Infusion of drugs into the third ventricle in rat was performed via indwelling cannulae. Drugs were infused at a volume of 10 μl over 2 min, and the infusion cannula was left in place for 2 min before removal. The formalin test was performed 10 min after drug administration.
Results
Intracerebroventricular administration of
d
-serine significantly and dose-dependently decreased the number of flinches in both the early and late phases in the formalin test. This antinociceptive effect was antagonized by intracerebroventricular administration of L-701,324, a selective antagonist at the glycine sites of NMDA receptors.
Conclusion
The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24048610</pmid><doi>10.1007/s00540-013-1708-3</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0913-8668 |
| ispartof | Journal of anesthesia, 2014-04, Vol.28 (2), p.228-234 |
| issn | 0913-8668 1438-8359 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A372958813 |
| source | Springer Link |
| subjects | Analgesics - administration & dosage Analgesics - therapeutic use Anesthesiology Animals Critical Care Medicine Drug therapy Emergency Medicine Formaldehyde Health aspects Infusions, Intraventricular Intensive Male Medicine Medicine & Public Health Nociception Original Article Pain Pain - chemically induced Pain - drug therapy Pain Measurement - drug effects Pain Medicine Quinolones - administration & dosage Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - agonists Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Serine Serine - administration & dosage Serine - therapeutic use |
| title | Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain |
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