Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain

Purpose In a previous study using the tail-flick test, we found that intracerebroventricular administration of d -serine, an endogenous co-agonist at the glycine sites of N -methyl- d -aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present s...

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Bibliographic Details
Published in:Journal of anesthesia 2014-04, Vol.28 (2), p.228-234
Main Authors: Ito, Miho, Yoshikawa, Masanobu, Ito, Kenji, Matsuda, Mitsumasa, Jin, Xing Lu, Takahashi, Shigeru, Kobayashi, Hiroyuki, Suzuki, Toshiyasu
Format: Article
Language:English
Subjects:
Analgesics - administration & dosage
Analgesics - therapeutic use
Anesthesiology
Animals
Critical Care Medicine
Drug therapy
Emergency Medicine
Formaldehyde
Health aspects
Infusions, Intraventricular
Intensive
Male
Medicine
Medicine & Public Health
Nociception
Original Article
Pain
Pain - chemically induced
Pain - drug therapy
Pain Measurement - drug effects
Pain Medicine
Quinolones - administration & dosage
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - agonists
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Serine
Serine - administration & dosage
Serine - therapeutic use
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Summary:Purpose In a previous study using the tail-flick test, we found that intracerebroventricular administration of d -serine, an endogenous co-agonist at the glycine sites of N -methyl- d -aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the effect of intracerebroventricular administration of d -serine on nociception induced by tissue damage or inflammation using the formalin test. Methods Infusion of drugs into the third ventricle in rat was performed via indwelling cannulae. Drugs were infused at a volume of 10 μl over 2 min, and the infusion cannula was left in place for 2 min before removal. The formalin test was performed 10 min after drug administration. Results Intracerebroventricular administration of d -serine significantly and dose-dependently decreased the number of flinches in both the early and late phases in the formalin test. This antinociceptive effect was antagonized by intracerebroventricular administration of L-701,324, a selective antagonist at the glycine sites of NMDA receptors. Conclusion The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain.
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-013-1708-3