Automated production of [sup.64]Cu prepared by 18 MeV cyclotron

[sup.64]Cu ([T.sub.1/2] = 12,7 h, [[beta].sup.-] 37,1%, [[beta].sup.+] 17,9%, EC 41%) is a useful radioisotopes for positron emission tomography radiopharmaceutical. We used the reaction route [sup.64]Ni(p,n) [sup.64]Cu for the [sup.64]Cu preparation. A basic disadvantage of this route, a high price...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2012-07, Vol.293 (1), p.217
Main Authors: Ometakova, J, Rajec, P, Csiba, V, Leporis, M, Stefecka, M, Vlk, P, Galambos, M, Rosskopfova, O
Format: Article
Language:English
Subjects:
Chromatography
Particle accelerators
PET imaging
Toy industry
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Summary:[sup.64]Cu ([T.sub.1/2] = 12,7 h, [[beta].sup.-] 37,1%, [[beta].sup.+] 17,9%, EC 41%) is a useful radioisotopes for positron emission tomography radiopharmaceutical. We used the reaction route [sup.64]Ni(p,n) [sup.64]Cu for the [sup.64]Cu preparation. A basic disadvantage of this route, a high price of the enriched target material, was eliminated by using very simple recycling procedure. Compact solid target irradiation system was installed at the end of the external beam line of the IBA Cyclone 18/9 cyclotron. In this paper, the irradiation of [sup.64]Ni target and separation of [sup.64]Cu from a target material is described. The separation was achieved by anion exchange chromatography with HCl as a elution solution. The distribution ratio for different HCl concentrations on Bio-Rad AG1-X8 and elution profile of [sup.64]Cu were investigated. [sup.64]Cu production rate for 100 mg [sup.64]Ni of 99.09% purity (ISOFLEX) on gold target was 104 MBq/[mu]Ah. The activity of the product was checked by ionisation chamber (Curiementor), gamma spectrometry using a HPGe detector and liquid scintillation counting using the triple-to-double coincidence ratio method. The separation process of [sup.64]Cu was made in a home-made separation module. Keywords PET * [sup.64]Ni * [sup.64]Cu * Automated production * Separation of [sup.64]Cu
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-012-1757-3