Investigation of activity of monoterpenes and phenylpropanoids against immature stages of Amblyomma cajennense and Rhipicephalus sanguineus (Acari: Ixodidae)

The objective of this study was to assess the acaricidal activity of carvacrol, thymol, eugenol, and (E)-cinnamaldehyde on unengorged larvae and nymphs of Amblyomma cajennense and Rhipicephalus sanguineus, using the modified larval packet test. Carvacrol, eugenol, and (E)-cinnamaldehyde were tested...

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Published in:Parasitology research (1987) 2013-10, Vol.112 (10), p.3471-3476
Main Authors: Senra, Tatiane Oliveira Souza, Calmon, Fernanda, Zeringóta, Viviane, Monteiro, Caio Márcio Oliveira, Maturano, Ralph, da Silva Matos, Renata, Melo, Diego, Gomes, Geovany Amorim, de Carvalho, Mario Geraldo, Daemon, Erik
Format: Article
Language:English
Subjects:
acaricidal properties
Acaricides - administration & dosage
Acaricides - chemistry
Acaricides - pharmacology
Amblyomma cajennense
Animals
Biomedical and Life Sciences
Biomedicine
carvacrol
Dose-Response Relationship, Drug
eugenol
Health aspects
Host-parasite relationships
Immunology
Ixodidae - drug effects
Larva - drug effects
larvae
Medical Microbiology
Microbiology
Monoterpenes - administration & dosage
Monoterpenes - pharmacology
mortality
nymphs
Original Paper
Phenylalanine
Physiological aspects
Propanols - administration & dosage
Propanols - chemistry
Propanols - pharmacology
Rhipicephalus sanguineus
Terpenes
thymol
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Summary:The objective of this study was to assess the acaricidal activity of carvacrol, thymol, eugenol, and (E)-cinnamaldehyde on unengorged larvae and nymphs of Amblyomma cajennense and Rhipicephalus sanguineus, using the modified larval packet test. Carvacrol, eugenol, and (E)-cinnamaldehyde were tested at concentrations of 2.5, 5.0, 10.0, 15.0, and 20.0 μl/ml, while thymol was tested at concentrations of 2.5, 5.0, 10.0, 15.0, and 20.0 mg/ml, in all cases with 10 repetitions per treatment. For the A. cajennense larvae, mortality rates caused by carvacrol, thymol, eugenol, and (E)-cinnamaldehyde at the lowest concentration were 45.0, 62.7, 10.2, and 81.6 %, respectively, reached 100 % at the concentration of 5.0 μl/ml for carvacrol and (E)-cinnamaldehyde and 5.0 mg/ml for thymol, while this mortality was observed at 15.0 μl/ml for eugenol. For the nymphs of this species, carvacrol and thymol caused 100 % mortality starting at a concentration of 5.0 μl/ml and 10.0 mg/ml, respectively, while eugenol caused 100 % mortality at 20.0 μl/ml and the mortality caused by (E)-cinnamaldehyde did not exceed 64 %. In the tests with R. sanguineus larvae, the lowest concentration of carvacrol and (E)-cinnamaldehyde resulted in 100 % mortality, while this percentage was observed starting at 10.0 μl/ml for eugenol. For nymphs, carvacrol and thymol at the smallest concentration caused 100 % lethality, unlike the results for eugenol and (E)-cinnamaldehyde, where 100 % mortality was only observed starting at the concentration of 10.0 μl/ml. The results obtained indicate that the tested substances have acaricidal activity on unengorged larvae and nymphs of A. cajennense and R. sanguineus.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-013-3527-8