Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo

A prenylated coumarin (diversin, 1) together with four new sesquiterpene lactones (diversolides A, D, F and G, 2-5) isolated from the roots of Ferula diversivittata were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecano...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2010-03, Vol.17 (3), p.269-273
Main Authors: Iranshahi, M., Sahebkar, A., Hosseini, S.T., Takasaki, M., Konoshima, T., Tokuda, H.
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Animals
Antigens, Viral - metabolism
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Beta carotene
Bioflavonoids
Cancer
Carcinogens
Care and treatment
Colon cancer
Coumarins - isolation & purification
Coumarins - pharmacology
Coumarins - therapeutic use
Curcumin
Development and progression
Diversin
EBV-EA activation
Female
Ferula - chemistry
Ferula diversivittata
Flavones
Flavonoids
Health aspects
Lactones - isolation & purification
Lactones - pharmacology
Lactones - therapeutic use
Mice
Mice, Inbred ICR
Monoterpenes - isolation & purification
Monoterpenes - pharmacology
Monoterpenes - therapeutic use
Papilloma - pathology
Papilloma - prevention & control
Physiological aspects
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Polyphenols
Sesquiterpenes
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Skin - drug effects
Skin - pathology
Skin Neoplasms - pathology
Skin Neoplasms - prevention & control
Tetradecanoylphorbol Acetate
Two-stage mouse skin carcinogenesis
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Summary:A prenylated coumarin (diversin, 1) together with four new sesquiterpene lactones (diversolides A, D, F and G, 2-5) isolated from the roots of Ferula diversivittata were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol-13-acetate (TPA). All of the tested compounds were active against EBV-EA activation. Among these compounds diversin (IC 50: 7.7) exhibited the strongest inhibitory effect and was selected to examine its effects on in vivo two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and TPA as promoter. Treatment with compound 1 (85 nmol) along with DMBA/TPA inhibited papilloma formation up to week 7 and the percentage of papilloma bearers was approximately 93.3% at week 20. The average number of papillomas formed per mouse was only 5.5 even at week 20. The results of the present investigation indicated that diversin might be valuable as a potent cancer chemopreventive agent and its potency was comparable with those of curcumin and quercetin, two well-known cancer chemopreventive agents.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2009.05.020