The effect of moderate-intensity exercise on the expression of HO-1 mRNA and activity of HO in cardiac and vascular smooth muscle of spontaneously hypertensive rats

The objective of this study was to observe the effects of moderate-intensity training on the activity of heme oxygenase (HO) and expression of HO-1 mRNA in the aorta and the cardiac muscle of spontaneously hypertensive rats (SHRs). After 9 weeks of swimming exercise, the activity of HO and expressio...

Full description

Saved in:
Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2016-04, Vol.94 (4), p.448-454
Main Authors: Ren, Cailing, Qi, Jie, Li, Wanwei, Zhang, Jun
Format: Article
Language:English
Subjects:
activité de l’HO
Animals
Aorta - drug effects
Aorta - metabolism
Blood Pressure - drug effects
Carbon Monoxide - blood
cardiac and vascular smooth muscle
Cardiovascular system
Care and treatment
Effects
entraînement physique
Exercise
expression de l’ARNm du gène HO-1
Gene expression
Health aspects
Heart - drug effects
Heart - physiopathology
Heme Oxygenase (Decyclizing) - metabolism
Heme Oxygenase-1 - metabolism
HO activity
HO-1 mRNA expression
Hypertension
Hypertension - chemically induced
Hypertension - metabolism
Male
Messenger RNA
Metabolic Networks and Pathways - drug effects
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
muscles cardiaque et vasculaire lisse
Physical Conditioning, Animal - physiology
Physiological aspects
Rats
rats spontanément hypertendus
Rats, Inbred SHR
Rats, Wistar
RNA, Messenger - metabolism
Rodents
Smooth muscle
spontaneously hypertensive rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study was to observe the effects of moderate-intensity training on the activity of heme oxygenase (HO) and expression of HO-1 mRNA in the aorta and the cardiac muscle of spontaneously hypertensive rats (SHRs). After 9 weeks of swimming exercise, the activity of HO and expression of HO-1 mRNA in the SHRs were measured. The resting blood pressure in the exercise group was increased by 1.7% (P > 0.05), whereas it was significantly elevated by 10.3% (P < 0.01) in the SHR rats. Compared with animals in the control and sedentary groups, the expression level of HO-1 mRNA of aorta and cardiac muscle in the exercise group was significantly enhanced (P < 0.01). The HO activity and the content of plasma carbon monoxide (CO) in the sedentary group were dramatically decreased (P < 0.05 and P < 0.01, respectively) compared with the control group. HO activity and content of plasma CO in the exercise group were significantly higher compared with those in the sedentary group (P < 0.05 and P < 0.01, respectively). The HO/CO metabolic pathway might be involved in the regulation of blood pressure of the SHR models.
ISSN:0008-4212
1205-7541
DOI:10.1139/cjpp-2015-0122