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Synthesis and Antimicrobial Activity of 5--3-pyrrolin-2-ones

A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized comp...

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Bibliographic Details
Published in:Russian journal of general chemistry 2020-07, Vol.90 (7), p.1222
Main Authors: Gein, V. L, Rubtsova, D. D, Bobyleva, A. A, Ryabova, O. V, Novikova, V. V, Kasimova, N. N, Yankin, A. N
Format: Article
Language:English
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Summary:A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized compounds was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220070087