Improving the synthesis of a molecularly imprinted sol-gel for serine using a Plackett-Burman design

We have studied the influence of the experimental conditions during synthesis on the properties of molecularly imprinted sol-gels for serine. The influence of hydrophobicity, presence of amino groups, additives, water/ethanol ratio and type of catalyst (basic or acid) were optimized using a Plackett...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2011-03, Vol.172 (3-4), p.351-356
Main Authors: Fernández-González, Alfonso, Badía-Laíño, Rosana, Díaz-García, Marta Elena
Format: Article
Language:English
Subjects:
Analytical Chemistry
Book publishing
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Exact sciences and technology
Microengineering
MIP
Molecular imprinting
Nanochemistry
Nanotechnology
Original Paper
Plackett-Burman
Serine
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Summary:We have studied the influence of the experimental conditions during synthesis on the properties of molecularly imprinted sol-gels for serine. The influence of hydrophobicity, presence of amino groups, additives, water/ethanol ratio and type of catalyst (basic or acid) were optimized using a Plackett-Burmann design in 12 blocks. Serine was selected as a target molecule for the imprinting process, and each imprinted and non-imprinted material was studied by competitive and non-competitive protocols. The results demonstrate the strong effect of 3-aminopropyltrimethoxysilane on the recognition capabilities of the materials in competitive assays. The mechanisms of interaction appear to be similar in acid-catalysed sol-gels, whereas sol-gels obtained under base catalysis tend to give interactions affecting the competitive experiments only. [graphic removed]
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-010-0497-8