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Preparation of a .sup.99mTc-labeled graft polymer and its in vitro and in vivo evaluation
The aim of this study is the synthesis of a novel .sup.99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with .sup.99mTc. The radiochemical yield of approximately the .sup.99mTc-labeled...
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Published in: | Journal of radioanalytical and nuclear chemistry 2021-08, Vol.329 (2), p.511 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The aim of this study is the synthesis of a novel .sup.99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with .sup.99mTc. The radiochemical yield of approximately the .sup.99mTc-labeled compound amounted to 97 ± 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate. |
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ISSN: | 0236-5731 1588-2780 |
DOI: | 10.1007/s10967-021-07817-6 |