N-Terminal pro C-Type Natriuretic Peptide

Ageing-related alterations in cardiovascular structure and function are commonly associated with chronic inflammation. A potential blood-based biomarker indicative of a chronic inflammatory state is N-Terminal Pro C-Type Natriuretic Peptide (NTproCNP). We aim to investigate associations between NTpr...

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Bibliographic Details
Published in:PloS one 2018-12, Vol.13 (12), p.e0209517
Main Authors: Keng, Bryan M. H, Gao, Fei, Tan, Ru San, Ewe, See Hooi, Teo, Louis L. Y, Xie, Bei Qi, Goh, George B. B, Koh, Woon-Puay, Koh, Angela S
Format: Article
Language:English
Subjects:
Biological markers
Care and treatment
Elderly
Health aspects
Myocardial diseases
Natriuretic peptides
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Summary:Ageing-related alterations in cardiovascular structure and function are commonly associated with chronic inflammation. A potential blood-based biomarker indicative of a chronic inflammatory state is N-Terminal Pro C-Type Natriuretic Peptide (NTproCNP). We aim to investigate associations between NTproCNP and ageing-related impairments in cardiovascular function. Community-based participants underwent same-day assessment of cardiovascular function and circulating profiles of plasma NTproCNP. Associations between cardiovascular and biomarker profiles were studied in adjusted models including standard covariates. We studied 93 participants (mean age 73 ± 5.3 years, 36 women), of whom 55 (59%) had impaired myocardial relaxation (ratio of peak velocity flow in early diastole E (m/s) to peak velocity flow in late diastole by atrial contraction A (m/s)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0209517