Amphetamine, Haloperidol, and Experience Interact to Affect Rate of Recovery after Motor Cortex Injury

Rats subjected to unilateral ablation of the motor cortex and placed on a narrow beam displayed transient contralateral paresis. An immediate and enduring acceleration of recovery was produced by a single dose of d-amphetamine given 24 hours after injury. This effect was blocked by haloperidol or by...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1982-08, Vol.217 (4562), p.855-857
Main Authors: Feeney, Dennis M., Gonzalez, Abel, Law, Wendy A.
Format: Article
Language:English
Subjects:
Animals
Brain damage
Catecholamines
Catecholamines - physiology
Dextroamphetamine - pharmacology
Dextroamphetamine - therapeutic use
Dosage
Drug Interactions
Fingers
Haloperidol - pharmacology
Light beams
Locomotion
Male
Medication administration
Motor Activity - drug effects
Motor cortex
Motor Cortex - physiology
Neurons
Paralysis - etiology
Paralysis - therapy
Physical trauma
Practice (Psychology)
Rats
Restraint, Physical
Wound Healing - drug effects
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Summary:Rats subjected to unilateral ablation of the motor cortex and placed on a narrow beam displayed transient contralateral paresis. An immediate and enduring acceleration of recovery was produced by a single dose of d-amphetamine given 24 hours after injury. This effect was blocked by haloperidol or by restraining the animals for 8 hours beginning immediately after amphetamine administration. A single dose of haloperidol given 24 hours after injury markedly slowed recovery. This effect was also blocked by restraining the animals.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7100929