Inhibition of Long-Term Potentiation by NMDA-Mediated Nitric Oxide Release

Activation of N-methyl-D-aspartate (NMDA) receptors before tetanic stimulation blocks long-term potentiation (LTP) in the CA1 region of the hippocampus. This NMDA-mediated inhibition of LTP can be reversed by the nitric oxide (NO) inhibitors L-N$^G$-monomethyl-arginine or hemoglobin and mimicked by...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-08, Vol.257 (5074), p.1273-1276
Main Authors: Izumi, Yukitoshi, Clifford, David B., Zorumski, Charles F.
Format: Article
Language:English
Subjects:
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Biological and medical sciences
Central nervous system
Electrophysiology
Fundamental and applied biological sciences. Psychology
Hemoglobins
Hemoglobins - pharmacology
Hippocampus - drug effects
Hippocampus - physiology
In Vitro Techniques
Long term potentiation
Methyl aspartate
Multidisciplinary Sciences
N methyl D aspartate receptors
N-methyl-D-aspartate
N-Methylaspartate - pharmacology
Neurons
Neuroscience
Nitric oxide
Nitric Oxide - metabolism
Nitroprusside - pharmacology
omega-N-Methylarginine
Oxides
Perfusion
Physiological aspects
Rats
Science & Technology
Science & Technology - Other Topics
Short-term memory
Synapses
Tetanus
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Activation of N-methyl-D-aspartate (NMDA) receptors before tetanic stimulation blocks long-term potentiation (LTP) in the CA1 region of the hippocampus. This NMDA-mediated inhibition of LTP can be reversed by the nitric oxide (NO) inhibitors L-N$^G$-monomethyl-arginine or hemoglobin and mimicked by sodium nitroprusside. These results indicate that the timing of NO release relative to high-frequency activation of CA1 synapses may be an important determinant of LTP generation and suggest that NO may play a positive or negative modulatory role in LTP depending on prior events at the tetanized synapse and the ambient concentration of excitatory amino acids.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1519065