Association between

IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in - to the risk of papillary thyroid carcinoma (PTC). - rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment leng...

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Bibliographic Details
Published in:Biomarkers in medicine 2017-02, Vol.11 (2), p.141-149
Main Authors: Nie, Xinwen, Yuan, Fang, Chen, Peng, Pu, Yan, Zhu, Jingqiang, Wang, Yichao, Xiao, Xue, Che, Guanglu, Gao, Linbo, Zhang, Lin
Format: Article
Language:English
Subjects:
papillary thyroid carcinoma
risk
rs153109
rs17855750
single nucleotide polymorphism
Online Access:Get full text
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Summary:IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in - to the risk of papillary thyroid carcinoma (PTC). - rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method. The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC. Significantly increased PTC risk was also associated with rs17855750 GT and GT/GG genotypes. Combined genotypes of rs153109 AG/GG and rs17855750 GT/GG increased the risk of PTC (p < 0.05). These findings showed that - rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2016-0283