Isolation of Two Polyketide Synthase Gene Fragments from the Uncultured Microbial Symbiont of the Marine Bryozoan Bugula neritina

"Candidatus Endobugula sertula," the uncultured microbial symbiont of the bryozoan Bugula neritina, produces ecologically and biomedically important polyketide metabolites called bryostatins. We isolated two gene fragments from B. neritina larvae that have high levels of similarity to poly...

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Bibliographic Details
Published in:Applied and Environmental Microbiology 2006-12, Vol.72 (12), p.7941-7944
Main Authors: Lopanik, Nicole B, Targett, Nancy M, Lindquist, Niels
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Aquatic life
Bacteria
Bacteria - genetics
Biological and medical sciences
Bryozoa - microbiology
Bugula neritina
DNA, Bacterial - analysis
DNA, Bacterial - genetics
DNA, Bacterial - isolation & purification
Endobugula sertula
Fundamental and applied biological sciences. Psychology
Genes
Invertebrate Microbiology
Marine
Microbiology
Molecular Sequence Data
Phylogeny
Polyketide Synthases - chemistry
Polyketide Synthases - genetics
Sequence Analysis, DNA
Symbiosis
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Summary:"Candidatus Endobugula sertula," the uncultured microbial symbiont of the bryozoan Bugula neritina, produces ecologically and biomedically important polyketide metabolites called bryostatins. We isolated two gene fragments from B. neritina larvae that have high levels of similarity to polyketide synthase genes. These gene fragments are clearly associated with the symbiont and not with the host.
ISSN:0099-2240
1098-5336
DOI:10.1128/AEM.01277-06