Frank H. George Research Award winning paper Cancer self-remission and tumour instability - a cybernetic analysis Towards a fresh paradigm for cancer treatment

Aims to investigate the causative factors and clinical applicability of spontaneous regression of malignant tumours without treatment, a really paradoxical phenomenon with many therapeutic potentialities. Analyses past cases to find that the commonest cause is a preceding episode of high fever-induc...

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Bibliographic Details
Published in:Kybernetes 2000-10, Vol.29 (7/8), p.896-927
Main Authors: Dutta Majumder, D, Roy, Prasun Kumar
Format: Article
Language:English
Subjects:
Cybernetics
Disease
Thermodynamics
Tumors
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Summary:Aims to investigate the causative factors and clinical applicability of spontaneous regression of malignant tumours without treatment, a really paradoxical phenomenon with many therapeutic potentialities. Analyses past cases to find that the commonest cause is a preceding episode of high fever-induced thermal fluctuation which produces fluctuation of biochemical immunological parameters. Using Prigogine-Glansdorff-Langevin stability theory and biocybernetic principles, develops the theoretical foundation of a tumour's self-control, homeostasis and regression induced by thermal, radiation or oxygenation fluctuations. Derives a threshold condition of perturbations for producing regression. Presents some striking confirmation of such fluctuation-induced regression in Ewing tumour, Clear cell cancer and Lewis lung carcinoma. Using experimental data on patients, elucidates a novel therapeutic approach of multi-modal hyper-fluctuation utilizing radiotherapeutic hyper-fractionation, temperature and immune-status.
ISSN:0368-492X
1758-7883
DOI:10.1108/03684920010342035