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Frank H. George Research Award winning paper Cancer self-remission and tumour instability - a cybernetic analysis Towards a fresh paradigm for cancer treatment
Aims to investigate the causative factors and clinical applicability of spontaneous regression of malignant tumours without treatment, a really paradoxical phenomenon with many therapeutic potentialities. Analyses past cases to find that the commonest cause is a preceding episode of high fever-induc...
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Published in: | Kybernetes 2000-10, Vol.29 (7/8), p.896-927 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Aims to investigate the causative factors and clinical applicability of spontaneous regression of malignant tumours without treatment, a really paradoxical phenomenon with many therapeutic potentialities. Analyses past cases to find that the commonest cause is a preceding episode of high fever-induced thermal fluctuation which produces fluctuation of biochemical immunological parameters. Using Prigogine-Glansdorff-Langevin stability theory and biocybernetic principles, develops the theoretical foundation of a tumour's self-control, homeostasis and regression induced by thermal, radiation or oxygenation fluctuations. Derives a threshold condition of perturbations for producing regression. Presents some striking confirmation of such fluctuation-induced regression in Ewing tumour, Clear cell cancer and Lewis lung carcinoma. Using experimental data on patients, elucidates a novel therapeutic approach of multi-modal hyper-fluctuation utilizing radiotherapeutic hyper-fractionation, temperature and immune-status. |
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ISSN: | 0368-492X 1758-7883 |
DOI: | 10.1108/03684920010342035 |