Nephrotic syndrome and Guillan-Barre syndrome : a rare association in child

Only few cases of nephrotic syndrome associated with Guillain-Barre Syndrome (GBS) have been reported in the adult and pediatric literature. A 3-year-old boy was initially admitted to our hospital following five days of progressive weakness of his extremities, fatigue, right leg pain and numbness. T...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2010, Vol.21 (1), p.135-137
Main Authors: Qarqash, Tahar, Mrad, Sonia Mazigh, Harz Allah, Qays, Bu Yahya, Ulfah, Azzah, Sumud al-Gharbi, Gharsallah, Lamya, Khalifi, Ibtisam, Bu Kathir, Samir
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biopsy
Care and treatment
Case studies
Child, Preschool
Diagnosis
Fatigue - etiology
Female
Guillain-Barre syndrome
Guillain-Barre Syndrome - complications
Guillain-Barre Syndrome - diagnosis
Guillain-Barre Syndrome - drug therapy
Guillain-Barré syndrome in children
Health aspects
Humans
Hypesthesia - etiology
Immunoglobulins, Intravenous - therapeutic use
Immunosuppressive agents
Leg
Male
Middle Aged
Muscle Weakness - etiology
Nephrotic syndrome
Nephrotic Syndrome - diagnosis
Nephrotic Syndrome - drug therapy
Nephrotic Syndrome - etiology
Nephrotic syndrome in children
Neurologic Examination
Pain - etiology
Patient outcomes
Risk factors
Steroids - therapeutic use
Treatment Outcome
الأطفال
التشخيص
المتلازمة الكلوية
المضاعفات
متلازمة غيلان باريه
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Summary:Only few cases of nephrotic syndrome associated with Guillain-Barre Syndrome (GBS) have been reported in the adult and pediatric literature. A 3-year-old boy was initially admitted to our hospital following five days of progressive weakness of his extremities, fatigue, right leg pain and numbness. There was no past history of renal or neurological disease. Cerebro­spinal fluid studies showed a protein level of 92 mg/dL and a white cell count of 1 per high-power field. The diagnosis of GBS was verified with a nerve conduction velocity test as well as. The GBS symptoms improved gradually on intravenous immunoglobulin. Three weeks later, he deve­loped severe proteinuria and edema; laboratory investigation showed nephrotic syndrome which responded to steroid therapy. Renal biopsy showed minimal change glomerulonephritis. He re­mained free of proteinuria during his 20 months of follow-up.
ISSN:1319-2442
2320-3838