Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma

Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viab...

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Bibliographic Details
Published in:Sarcoma 2012, Vol.2012 (2012), p.1-10
Main Authors: Smeland, Eivind, Kilvaer, Thomas Karsten, Sorbye, Sveinung, Valkov, Andrej, Andersen, Sigve, Bremnes, Roy M., Busund, Lill-Tove, Donnem, Tom
Format: Article
Language:English
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Summary:Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers. Results. In univariate analyses, GLUT-1 (P
ISSN:1357-714X
1369-1643