Value of serum cystatin C as a marker of renal function in the early post kidney transplant period

Management of renal transplant patients requires periodic measurement of renal function especially in early post-transplant period. This is usually assessed by measuring the cretonne clearance, but because of its limitations, it is not an ideal marker for assessing the renal function. Serum Cyst tin...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2009-11, Vol.20 (6), p.1015-1017
Main Authors: Malik Husayni, Sayyid Ali, Malekpour, Zahrah, Bani Hashimi, Mehrzad, Yaghoobi, Ramin, Aghdaie, Mahdukht Husayn, Jalali, Ghanbar Ali Raiss, Azarpira, Negar, Ayat Allah, Maryam, Gerami zadah, Bita
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Biomarkers - urine
Complications
Creatinine - blood
Creatinine - urine
Cystatin C - blood
Cystatins
Female
Glomerular Filtration Rate - drug effects
Graft Rejection - blood
Graft Rejection - etiology
Graft Rejection - physiopathology
Graft Rejection - prevention & control
Humans
Immunosuppressive Agents - therapeutic use
Kidney - drug effects
Kidney - physiopathology
Kidney - surgery
Kidney function tests
Kidney Transplantation - adverse effects
Kidneys
Male
Medical research
Medicine, Experimental
Middle Aged
Predictive Value of Tests
Prospective Studies
Time Factors
Transplantation
الأمراض
البروتينات
التشخيص
الفحوصات الطبية
الكلى
المضاعفات
زرع الأعضاء
سيستاتين سي
وظائف الكلى
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Summary:Management of renal transplant patients requires periodic measurement of renal function especially in early post-transplant period. This is usually assessed by measuring the cretonne clearance, but because of its limitations, it is not an ideal marker for assessing the renal function. Serum Cyst tin C (sCyC) appears to be an endogenous marker of glomerular filtration rate (GFR). To assess the use of sCyC as a marker of renal function in kidney transplant patients, we compared it with serum cretonne (sCr) and 24-hour urine cretonne clearance (CrCl) in the first week post-transplantation. Among 60 patients (62.8 % men, 37.2 % women) undergoing kidney transplantation (average age: 44.87 ± 13.37 years), we determined renal function at 1, 3, 5, and 7 days after kidney transplantation using: sCr, sCyC and CrCl in a 24-hours urine specimen. During the first 5 days following transplantation, there was a progressive decline in sCr levels. In the first 5 days, post transplantation we could not find good correlation between CrC and sCyC, and the sCyC increased during these 5 days, but after that in day 7, there was a good correlation between CrC and sCyC which is coinciding with decreasing the dose of steroid (r = .625). Therefore, we recommend using sCyC may be used as a marker of renal function after one-week post kidney transplantation.
ISSN:1319-2442
2320-3838